Papaverine 20 mg 10 pcs. rectal suppositories

Smooth muscle spasms: of the abdominal organs (in cholecystitis, pylorospasm, spastic colitis); in renal colic; of peripheral vessels (in endarteritis); of cerebral vessels (in migraine); of the heart (in angina pectoris – as part of combination therapy); of the bronchi (in bronchospasm).

Rectally. Remove the suppository from the blister pack and insert it into the rectum. Use 1 suppository 2-3 times a day after spontaneous bowel movement or cleansing enema.

Composition per suppository: active ingredient: papaverine hydrochloride – 20 mg;
excipients: solid fat (Vitepsol (grades H 15, W 35), Supposir (grades NA 15, NAS 50)) - up to a total suppository weight of 1.25 g.

Suppositories of torpedo shape, from white to white with a yellowish or creamy tint. The appearance of a white coating on the surface of the suppository is permissible.

Hypersensitivity to the components of the drug; atrioventricular block; glaucoma; severe liver failure; elderly age (risk of hyperthermia); childhood, as the dosing regimen for children is not specified.

During the treatment with the drug, alcohol consumption should be excluded.
The vasodilatory effect is reduced with smoking.

Possible allergic reactions; atrioventricular block; ventricular extrasystole; increased activity of liver transaminases; decreased blood pressure; drowsiness; constipation; eosinophilia.

Symptoms: diplopia, weakness, decreased blood pressure, drowsiness.
Treatment: symptomatic (blood pressure support).

Papaverine reduces the antiparkinsonian effect of levodopa and the hypotensive effect of methyldopa. In combination with barbiturates, the antispasmodic action of papaverine is enhanced. When used together with tricyclic antidepressants, procainamide, reserpine, and quinidine, an increase in the hypotensive effect may occur.

Papaverine hydrochloride is a myotropic antispasmodic agent. It inhibits phosphodiesterase, leading to the accumulation of cyclic 3,5-adenosine monophosphate (AMP) in the cell and a decrease in calcium content. It relaxes the smooth muscles of internal organs (gastrointestinal tract, respiratory tract, urogenital system) and blood vessels. In high doses, it reduces the excitability of the cardiac muscle and slows down intraventricular conduction. The effect of papaverine on the central nervous system is weakly expressed, but in high doses, it has a sedative effect.

The bioavailability of papaverine after rectal administration (according to preclinical studies) is approximately 25%. Plasma protein binding is 90%. It is well distributed and penetrates histohematologic barriers. It is metabolized in the liver. The half-life (T1/2) is 0.5-2 hours (possibly extending up to 24 hours). It is excreted by the kidneys in the form of metabolites.

The drug Papaverine 20 mg is a rectal suppository used for the treatment of smooth muscle spasms in the abdominal organs. It contains the active ingredient papaverine hydrochloride, which promotes muscle relaxation, alleviating spasms and pain in the gastrointestinal tract, urinary tract, and female reproductive organs. The suppositories are easy to insert into the rectum and are quickly absorbed, starting to take effect within a few minutes after administration. This medication is readily available and has a convenient dosage form, making it popular for the treatment of various conditions.