Probifor 500 million/10 capsules

• diarrhea of various etiologies;

• food toxic infections;

• acute intestinal infections of bacterial and viral nature (salmonellosis, shigellosis, enterocolitis caused by pathogenic representatives of the Enterobacteriaceae family or staphylococci, rotavirus infection) or of unknown etiology;

• dysbiosis of various etiologies, including those developed against the background of and after the use of antibiotics, cytostatic and radiation therapy; complicating the course of viral hepatitis, liver cirrhosis, diverticulosis of various localizations;

• newborns (including premature) children with a complicated premorbid background, starting from the period of stay in the maternity hospital, to improve the course of the adaptation period, as well as in cases of pronounced dysbiosis;

• pregnant women in preparation for childbirth, cesarean section, and in the postoperative period. The drug is used as part of combination therapy

• chronic infectious and nonspecific inflammatory diseases of the digestive tract (gastroduodenitis, pancreatitis, proctosigmoiditis, colitis, including ulcerative colitis);

• patients with secondary immunodeficiency states, in severe infectious-inflammatory and purulent-septic diseases (sepsis, peritonitis, etc.); with skin diseases (atopic dermatitis, streptoderma, eczema);

• irritable bowel syndrome;

• acute respiratory viral infections and influenza;

• surgical patients (including those with traumatic profiles) for preoperative preparation and prevention of postoperative complications; in post-gastrectomy disorders and conditions after cholecystectomies;

• oncological patients undergoing chemotherapy, radiation therapy, before and after surgical interventions

The drug is used for children from the newborn period and adults. In case of acute intestinal infection, food toxicoinfection, diarrhea:

• for children under 6 months, 1 capsule 2 times a day; for children over 6 months, 1 capsule 3-4 times a day (possibly with a short interval of 2-3 hours), for a course of 2-3 days; if clinical symptoms persist, the treatment course is extended to 4-5 days;

• for children over 7 years and adults, 2-3 capsules 2 times a day, treatment course 3-5 days,

• for adults to stop diarrhea in the early stages of the disease, 3 capsules 2 times a day with an interval of 30 minutes - 1 hour, the dosage can be increased to 6 capsules taken at once once a day, treatment course 1-3 days.
In chronic gastrointestinal pathology, irritable bowel syndrome - for children, 3 capsules taken once during the evening meal, for adults, 3 capsules taken once or 2 capsules 2 times a day. Treatment course 5-15 days. In severe disease progression, the amount of the drug taken can be increased for adults and children to 6 capsules per day, and the treatment course can be extended to 30 days.
In dysbiosis of various etiologies, chronic intestinal infections, in patients with immunodeficiency conditions, with skin diseases, as well as to improve the course of the adaptation period in newborns:

• for premature newborns, 1 capsule 1-2 times a day;

• for full-term newborns and children under 3 years, 1 capsule 2 times a day;

• for children from 3 to 7 years - 1 capsule 3 times a day;

• for children over 7 years and adults, 2-3 capsules 2 times a day. Treatment course 7-10 days.
In the complex treatment of acute respiratory viral infections and influenza - for patients of all age groups from day 1-2 of the disease, 1 capsule 3 times a day. Treatment course 2 days.
For surgical patients, pregnant women preparing for cesarean section to reduce postoperative complications:

• before the operation, 1 capsule 3 times a day for 2-3 days; for individuals suffering from intestinal dysbiosis who have received antibiotics and chemotherapeutic agents, the preoperative course is extended to 7 days,

• from day 2-7 after the operation, 1 capsule 3 times a day for 2-3 days, as indicated - 7-10 days.
Probifor® is taken orally during meals, if necessary, regardless of meals, with water. For children and patients who cannot swallow a whole capsule, it is opened. The contents of the capsule are mixed with liquid food, preferably a dairy product, for newborns and infants - with breast milk or formula. The contents of the capsule can be mixed with 10-50 ml of boiled water at room temperature, resulting in a cloudy suspension with black sorbent particles. The resulting aqueous suspension should be drunk without aiming for complete dissolution.

PRECAUTIONS FOR USE
There are no precautions.

One capsule contains: active ingredient: bifidobacteria B.bifidum, adsorbed on activated carbon - at least 500 million (5x10⁷) CFU*, excipient - lactose monohydrate - up to 0.20 g. *CFU - colony-forming unit

Capsule No. 3 is a hard gelatin capsule of cylindrical shape with hemispherical ends. The body of the capsule is opaque white, and the cap is opaque yellow. The contents of the capsule are a powder with a weak sour-milk smell, ranging in color from light gray to dark gray with black particles of charcoal.

Contraindications

Congenital lactase deficiency, glucose-galactose malabsorption, increased sensitivity to the components of the drug.

Special Instructions

USE DURING PREGNANCY AND LACTATION

Probifor® is approved for use by women during pregnancy and breastfeeding. There are no special conditions for use.

SPECIAL INSTRUCTIONS

Not suitable for use after the expiration date, if there are changes in appearance, if labeling is missing or unclear, or if there is evidence of damage to the primary packaging before first opening.

INFLUENCE OF THE DRUG ON THE ABILITY TO DRIVE VEHICLES AND OPERATE MACHINERY

Probifor® does not affect the ability to drive vehicles or operate machinery.

Side effects

Not established

Overdose

There have been no reported cases of overdose.

Interaction

When taken simultaneously with vitamins (especially B group), the effect of the drug is enhanced. When used concurrently with antibiotics, a decrease in the effect of the Probifor® drug may occur - when taking antibiotics, the recommended interval between the intake of the antibiotic and the Probifor® drug is 3-4 hours.

PHARMACODYNAMICS

Biological Properties
The antidiarrheal effect of the drug is due to the high concentration of bifidobacteria (Bifidobacterium bifidum № 1) adsorbed on the particles of activated charcoal, which are antagonists of a wide range of pathogenic (shigella, salmonella, golden staphylococcus, etc.) and conditionally pathogenic microorganisms (proteus, klebsiella, etc.).
The anti-infective action of the drug is enhanced by the adsorption of bifidobacteria on charcoal particles, leading to accelerated normalization of the gastrointestinal microbiocenosis, activation of restorative processes in the mucous membranes, and increased anti-infective resistance of the body.
The antitoxic action of the drug is ensured by the rapid colonization of the intestines by microcolonies of bifidobacteria, restoration of normal microflora, which prevents the penetration of toxins into the internal environment of the body and, being a natural biosorbent, accumulates significant amounts of toxic substances that enter from outside or are formed in the body.
Bifidobacteria in high concentrations activate the brush-border digestion of the intestine, synthesize vitamins and amino acids, enhance the protective function of the intestine, and boost the immune defense of the body.

Description

Probifor 500 million/portion is a medicinal product. The anti-diarrheal action of the drug is due to the high concentration of bifidobacteria (Bifidobacterium bifidum No. 1) adsorbed on activated carbon particles, which are antagonists of a wide range of pathogenic (shigella, salmonella, golden staphylococcus, etc.) and conditionally pathogenic microorganisms (proteus, klebsiella, etc.). Bifidobacteria in high concentrations activate the brush border digestion of the intestine, synthesize vitamins and amino acids, enhance the protective function of the intestine, and the immune defense of the body.

Indications: diarrhea of various etiologies; food toxic infections; acute intestinal infections of bacterial and viral nature; dysbiosis of various etiologies, including those developed against the background of and after the use of antibiotics, cytostatic, radiation therapy; for newborns (including premature) to improve the course of the adaptation period, as well as in cases of pronounced dysbiosis; for pregnant women in preparation for childbirth, cesarean section, and in the postoperative period.

The drug is used for children from the neonatal period and adults. It is recommended to consult a doctor before use.

STORAGE CONDITIONS
Store at a temperature of 2 to 10 °C.
Transportation of the drug at a temperature not exceeding 25 °C is allowed for no more than 10 days.