Miramistin 0.01% Solution for Local Use

Indications

The Miramistin® preparation is used in adults and children:
• in otorhinolaryngology (ear, throat, and nose diseases): for the comprehensive treatment of acute and chronic external otitis, sinusitis, tonsillitis, pharyngitis, laryngitis;
• in dentistry (diseases of teeth, gums, and the oral cavity as a whole): for the treatment and prevention of infectious-inflammatory diseases of the oral cavity (stomatitis, gingivitis, periodontitis), hygienic treatment of removable dentures;
• in surgery, traumatology: for the prevention of purulent infections and treatment of purulent wounds, treatment of purulent-inflammatory processes of the musculoskeletal system;
• in obstetrics, gynecology: for the prevention and treatment of purulent infections of postpartum injuries, perineal and vaginal wounds, postpartum infections, inflammatory diseases (vulvovaginitis);
• in burn care (burn injuries): for the treatment of superficial and deep burns of II and IIIA degrees, preparation of burn wounds for dermatoplasty (plastic surgeries, such as skin grafting);
• in dermatology (bacterial and fungal skin infections): for the treatment and prevention of pyodermas and dermatomycoses, foot mycoses, candidiasis of the skin and mucous membranes;
• in venereology: for individual prevention of sexually transmitted diseases (syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis);
• in urology (diseases of the urogenital system): for the comprehensive treatment of acute and chronic urethritis and urethroprostatitis of specific (chlamydia, trichomoniasis, gonorrhea) and nonspecific origin.

Always use the medication in full accordance with the leaflet or the recommendations of your treating physician. If in doubt, consult your treating physician. Recommended dosage Otolaryngology • Tonsillitis, pharyngitis, laryngitis: 3-4 presses on the spray nozzle or 10-15 ml for one gargle 3-4 times a day. • In case of acute and chronic otitis externa: instill up to 5 drops of the medication into the external auditory canal using a pipette 4 times a day or instead of instillation, gently insert a gauze tampon soaked with the medication into the external auditory canal 4 times a day. The treatment course is 10 days. • In case of sinusitis: during puncture, the maxillary sinus is washed with a sufficient amount of the medication. The duration of therapy is from 4 to 10 days depending on the onset of remission. Dentistry • In case of stomatitis, gingivitis, periodontitis, it is recommended to gargle with 10-15 ml of the medication 3-4 times a day. If gargling is not possible, local application of gauze or cotton swabs soaked with the solution of the medication is allowed. Surgery, Traumatology, Combustiology • For the treatment and prevention of secondary infection of wounds:

• the wound surface is irrigated with the medication;

• gauze tampons soaked with the medication are fixed on the wound surface;

• if necessary, tamponade of the wound and/or fistulous tracts may be performed during surgical manipulations;

• active drainage of wounds and/or cavities may be performed. The daily consumption of the medication is up to 1 liter.

• Obstetrics, Gynecology • Prevention and treatment of purulent infections of postpartum injuries, perineal and vaginal wounds, postpartum infections: the medication is used for vaginal irrigations before childbirth (5-7 days), during childbirth (after each vaginal examination). In the postpartum period, the medication is introduced using tampons soaked with 50 ml of the medication for 2 hours daily for 5 days. • In case of cesarean section, the vagina is treated immediately before the operation, during the operation - the uterine cavity and the incision on it, and in the postoperative period, tampons soaked with Miramistin® are introduced for 2 hours daily for 7 days. • Treatment of inflammatory diseases is carried out for a course of 2 weeks by intravaginal introduction of tampons with Miramistin®, as well as by the method of drug electrophoresis. • Comprehensive treatment of inflammatory diseases in gynecology (vulvovaginitis): in the form of vaginal irrigations or introduction of a tampon soaked with Miramistin® for 2 hours daily for 7-14 days (the duration of treatment and frequency of administration are determined by the physician's prescription). For convenience of vaginal irrigation, the use of a gynecological nozzle is recommended. The contents of the bottle should be introduced into the vagina using the gynecological nozzle and irrigation should be performed. Dermatology • Treatment and prevention of pyodermas and dermatomycoses, candidiasis of the skin and mucous membranes, mycoses of the feet: the medication is applied to the affected area of the skin by wiping with sterile gauze swabs abundantly soaked with the medication. The medication is used 3 times a day on the affected areas of the skin. Venereology • Prevention of sexually transmitted diseases: the use of the medication is effective within 2 hours after sexual intercourse.

• The contents of the bottle should be introduced into the urethra using a urological applicator for 2-3 minutes: men: 2-3 ml of the medication, women: 1-2 ml of the medication into the urethra and 5-10 ml into the vagina (for convenience, the use of a gynecological nozzle is recommended).

• Treat the skin of the inner surfaces of the thighs, pubis, and genitals.

• After the procedure, it is recommended not to urinate for 2 hours. Urology • In the comprehensive treatment of urethritis and urethroprostatitis, inject 2-3 ml of the medication into the urethra 1-2 times a day, course - 10 days. Use in children and adolescents Otolaryngology • In case of sinusitis, acute and chronic otitis externa, the dosing regimen for children from 0 to 18 years does not differ from the dosing regimen for adults. • Tonsillitis, pharyngitis, laryngitis:

• children 3-6 years: a single press on the spray nozzle or 3-5 ml for one gargle 3-4 times a day;

• children 7-14 years: double press on the spray nozzle or 5-7 ml for one gargle 3-4 times a day.

• The dosing regimen for children from 14 to 18 years does not differ from the dosing regimen for adults. The duration of therapy is from 4 to 10 days depending on the onset of remission (improvement). Dentistry, surgery, traumatology, combustiology, dermatology • The dosing regimen for children from 0 to 18 years does not differ from the dosing regimen for adults. Obstetrics, gynecology, urology • The method of application, duration of treatment, and frequency of administration are determined by the physician's prescription.

Instructions for using the medication:

The medication is ready for use. The medication is used in the form of irrigations, gargles, and applications.

Instructions for using the 50 ml, 150 ml packaging with a screw cap included with a spray nozzle 1.Remove the cap from the bottle. 2.Remove the attached spray nozzle from the protective packaging. 3.Attach the spray nozzle to the bottle, positioning the spray nozzle vertically. 4.Activate the spray nozzle with repeated presses (at least 7 presses). 5.When irrigating the throat, position the spray nozzle horizontally.

Instructions for using the 50 ml packaging with a gynecological nozzle 1.Remove the cap from the bottle. 2.Remove the attached gynecological nozzle from the protective packaging. 3.Attach the gynecological nozzle to the bottle without removing the urological applicator.

Instructions for using the 150 ml packaging with a screw cap included with a spray nozzle and measuring cup For using the medication in the form of gargling, the amount of medication needed for one gargle should be measured using the measuring cup included in the package.

Instructions for using the spray nozzle are described in the section "Instructions for using the 50 ml, 150 ml packaging with a screw cap included with a spray nozzle".

Duration of therapy Use the medication for as long as recommended by your treating physician.

If you forgot to use Miramistin® If you forgot to use Miramistin®, use it as soon as you remember. Do not use a double dose to make up for a missed one. If you have questions about using the medication, consult your treating physician or a pharmacy worker.

Section: Composition

The Miramistin® preparation contains
The active ingredient is benzildimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate.
Each 1 ml of the solution for local use contains 0.1 mg (0.01%) of benzildimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate.
The other ingredient (excipients) is purified water.

Description of the dosage form

Colorless transparent liquid, foaming upon shaking.

Contraindications

Do not use the Miramistin® preparation:
- if you are allergic to benzildimethyl-myristoylamino-propylammonium or any other components of the preparation (listed in section 6 of the leaflet);
- for irrigating the throat and tonsils in children under 3 years of age due to the risk of reactive laryngospasm (narrowing of the larynx, which can cause difficulty in breathing).

Special instructions

Before using the Miramistin® medication, consult with your treating physician, pharmacist, or nurse.
Using one bottle of the medication by more than one person may lead to the spread of infection.

Section: Side Effects

Like all medications, Miramistin® may cause undesirable reactions, but they do not occur in everyone.
Discontinue the use of Miramistin® and seek medical attention immediately if any of the following undesirable reactions occur:
Very rare (may occur in no more than 1 in 10,000 people)
• allergic reactions (may manifest as difficulty breathing or swallowing, swelling of the face, lips, tongue, or throat).
Other possible undesirable reactions that may be observed with the use of Miramistin®:
Very rare (may occur in no more than 1 in 10,000 people)
• mild burning sensation that passes on its own within 15-20 seconds and does not require discontinuation of the medication.

Reporting Adverse Reactions
If you experience any undesirable reactions, consult a doctor, pharmacist, or nurse. This recommendation applies to any possible undesirable reactions, including those not listed in the leaflet. You can also report adverse reactions directly through the reporting system of the member state of the Eurasian Economic Union. By reporting adverse reactions, you help gather more information about the safety of the medication.

Section: Overdose

If you have used Miramistin® more than intended
No cases of overdose of the drug with local application have been reported. If you have used Miramistin® more than intended, consult a doctor.

Interaction

Inform your treating physician or pharmacist about any other medications you are taking, have recently taken, or may start taking.
When used simultaneously with Miramistin®, an enhancement of their antibacterial and antifungal properties has been noted.

Section: Pharmacodynamics

What the drug Miramistin is and what it is used for
The drug Miramistin® contains the active substance benzildimethyl-myristoylaminopropylammonium, which belongs to the group of antiseptic medications. Miramistin® causes the death of bacteria, fungi, and viruses capable of causing infections in humans, as well as preventing the infection of wounds and burns, and accelerating healing.

Mechanism of action of the drug Miramistin
Miramistin® has a wide spectrum of antimicrobial action: it exhibits pronounced bactericidal action (destroys bacteria) and antifungal action. It has antiviral properties and is active against complex viruses (herpes viruses, human immunodeficiency virus). It acts on the pathogens of sexually transmitted diseases (syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis).
It effectively prevents the infection of wounds and burns. It activates tissue restoration processes (regeneration). It does not have local irritant effects or allergenic properties.
If improvement does not occur within 3 days or if you feel worse, you should consult a doctor.

Описание

Miramistin is an antiseptic agent intended for local use. Developed based on benzyl dimethyl ammonium chloride, it has high effectiveness in combating microbes, bacteria, and viruses.

Miramistin is effective for treating various skin and mucous membrane diseases, including: burns, wounds, cuts, infected inflammations, purulent diseases, etc.

The packaging of the 150 ml spray bottle allows for easy and convenient use of the drug at home. Miramistin does not cause irritation to the skin and mucous membranes, has no odor, does not stain fabrics, and leaves no marks on clothing.

This drug is an essential item in the first aid kit of every home for providing quality and rapid treatment of skin and mucous membrane injuries. Its high effectiveness and safety of use are confirmed by many years of application experience.