Magnesium Plus 10 effervescent tablets

Prevention of magnesium deficiency and related conditions: neuromuscular disorders (muscle weakness, tremors, spasms, cramps); mental disorders (insomnia, irritability, anxiety); cardiac rhythm disturbances and gastrointestinal tract dysfunction (pain, spasms, bloating).

Orally.
Adults and children over 12 years: 1-2 tablets.
Children from 6 to 12 years: 1/2 tablet.
Take in the first half of the day, dissolving in a glass of water beforehand.

Composition per tablet:
Active ingredients:
Magnesium lactate.......................................................................................200.0 mg
Magnesium carbonate................................................................................100.0 mg
Pyridoxine hydrochloride (Vitamin B6)........................................................2.0 mg
Folic acid (Vitamin B9)................................................................................0.2 mg
Cyanocobalamin 0.1% (Vitamin B12 0.1%)....................................................1.000 mg
calculated as Vitamin B12...........................................................................0.001 mg
Excipients: sodium bicarbonate 800.0 mg; citric acid 1300.0 mg; sodium saccharin dihydrate 10.0 mg; sorbitol 966.8 mg; macrogol 40.0 mg; lime flavoring 80.0 mg.

Round flat-cylindrical tablets with a beveled edge, white or white with a slight yellowish-green tint, with a score line on one side, having a faint specific odor.

Severe renal insufficiency (creatinine clearance less than 30 ml/min); increased sensitivity to the components of the product; age under 6 years.
With caution: the product should be prescribed in cases of moderate renal function impairment due to the risk of developing hypermagnesemia.
Pregnancy and lactation:
During pregnancy and lactation, the use of the product is possible with caution and based on indications, as the need for magnesium significantly increases during this time. If its levels are not balanced, this may lead to serious complications, including miscarriage.
Magnesium passes into breast milk, therefore, the use of the product should be avoided during breastfeeding.

In the case of concomitant calcium deficiency, magnesium deficiency must be corrected before starting additional calcium intake.
With frequent use of laxatives, alcohol, and increased physical and mental stress, the need for magnesium increases.
The drug does not affect the ability to drive vehicles and operate potentially dangerous machinery.

Allergic reactions; dyspeptic disorders (diarrhea, abdominal pain). When used in increased doses, hypermagnesemia may develop.

Symptoms of overdose: drop in blood pressure, nausea, vomiting, slowed reflexes, respiratory depression, coma, cardiac arrest, and heart paralysis, anuria.
Treatment: rehydration, forced diuresis. In cases of renal failure, hemodialysis or peritoneal dialysis is necessary.

Phosphates and calcium salts reduce the absorption of magnesium in the gastrointestinal tract. Magnesium preparations decrease the absorption of tetracycline; it is recommended to allow a 3-hour interval before using MAGNESIUM PLUS. Pyridoxine may weaken the effect of levodopa.

Magnesium is an essential element. It plays a crucial role in the functioning of the nervous system, participates in the regulation of nerve impulse transmission and muscle contraction, is involved in most metabolic reactions, plays an important physiological role in maintaining ionic balance, and participates in energy processes (ATP, which is a chemical source of energy, can only enter the energy formation process in the form of a magnesium salt).

Vitamin B6 plays an important role in metabolism, helps maintain the structure and function of bones, teeth, and gums; influences erythropoiesis, supports the normal functioning of the nervous system, and complements the effect of magnesium.

Vitamin B12 and folic acid are involved in many enzymatic reactions and have a beneficial effect on the nervous and hematopoietic systems.

Absorption of magnesium in the gastrointestinal tract is no more than 50% of the administered dose. In the body, 99% of magnesium is found inside cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, while 1/3 is found in smooth and striated muscle tissue. It is excreted in urine. Glomerular filtration is 70% of plasma, and tubular reabsorption is 95-97%. At least 1/3 of the administered magnesium dose is excreted in urine.

Pyridoxine hydrochloride is rapidly absorbed throughout the small intestine, with a greater amount absorbed in the jejunum. It is metabolized in the liver to form pharmacologically active metabolites (pyridoxal phosphate and pyridoxamine phosphate). Pyridoxal phosphate binds to plasma proteins at 90%. It penetrates well into all tissues; it is predominantly accumulated in the liver, less so in muscles and the CNS. It crosses the placenta and is secreted in breast milk. T1/2 is 15-20 days. It is excreted by the kidneys (with intravenous administration - 2% in bile), as well as during hemodialysis. About 8-10% of the drug is excreted unchanged in urine.

Folic acid is well and completely absorbed in the gastrointestinal tract, predominantly in the upper sections of the duodenum. It intensely binds to plasma proteins. It crosses the blood-brain barrier, the placenta, and is present in breast milk. The time to reach maximum concentration is 60 minutes. It is deposited and metabolized in the liver to form tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase). It is excreted by the kidneys predominantly as metabolites.

Cyanocobalamin is absorbed in the small (partly in the large) intestine, where it binds to intrinsic factor, becoming protected from intestinal microflora. In the blood, cyanocobalamin binds to transcobalamin I and II, with which it is transported to tissues. Cyanocobalamin is mainly deposited in the liver, excreted from the liver with bile into the intestine, from where it is reabsorbed. It is eliminated from the body by the kidneys. After oral administration, up to 2 mg is absorbed 30-97%; absorption of the drug (dependent on intrinsic factor absorption) significantly decreases after doses greater than 2 mg. Binding to plasma proteins is 90%. Cmax after oral administration is reached in 6-14 hours. T1/2 in the liver is 500 days. It is excreted with normal kidney function - 7-10% by the kidneys, about 50% with fecal matter; with reduced kidney function - 0-7% by the kidneys, 70-100% with fecal matter. It crosses the placental barrier and is present in breast milk.

Magnesium Plus is a medicinal product used in the following cases: prevention of magnesium deficiency and related conditions: neuromuscular disorders (muscle weakness, tremors, spasms, cramps), mental disorders (insomnia, irritability, anxiety), cardiac rhythm disturbances, and gastrointestinal tract issues (pain, spasms, bloating).

It consists of 10 effervescent tablets, each containing magnesium, which plays an important role in the functioning of the nervous system, participates in the regulation of nerve impulse transmission and muscle contraction, is involved in most metabolic reactions, plays a crucial physiological role in maintaining ionic balance, and participates in energy processes. Additionally, it contains vitamins B6, B9, and B12, which help maintain the structure and function of bones, teeth, and gums; influence erythropoiesis; support the normal functioning of the hematopoietic and nervous systems; and complement the effect of magnesium.

With regular use, Magnesium Plus improves heart function, reduces stress levels, and enhances the body's resistance to diseases. It is an excellent remedy recommended for supporting overall health. Consultation with a physician is advised before use.