Broad-spectrum antibiotic; contains a semisynthetic penicillin, amoxicillin and β-lactamase inhibitor clavulanic acid. Clavulanic acid provides stable inactivated complex with these enzymes and provides resistance to the effects of amoxicillin β-lactamases produced by microorganisms.
Clavulanic acid, similar to the structure of beta-lactam antibiotics, has its own weak antibacterial activity.
Amoxiclav has a broad spectrum of antibacterial action. Active otnosheniichuvstvitelnyh to amoxicillin strains, including strains producing β-lactamase, including Aerobic gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Enterococcus spp, Staphylococcus aureus (except methicillin-resistant strains), Staphylococcus epidermidis (except methicillin-resistant strains), Staphylococcus saprophyticus, Listeria spp; aerobic gram-negative bacteria.. : Bordetella pertussis, Brucella spp, Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae, Helicobacter pylori, Klebsiella spp, Moraxella catarrhalis, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida, Proteus spp, Salmonella spp,…. Shigella spp, Vibrio cholerae, Yersinia enterocolitica, Eikenella corrodens.; Gram-positive anaerobes: Peptococcus spp, Peptostreptococcus spp, Clostridium spp, Actinomyces israelii, Fusobacterium spp, Prevotella spp, Gram-negative anaerobes:….. Bacteroides spp
Amoxicillin, Clavulanic acid
Lek dd, Slovenia
Children older than 3 months, children on prescription
5ml of finished suspensions contain amoxicillin (in trihydrate form) and 125 mg of clavulanic acid (as potassium salt) 31.25 mg;
Excipients: anhydrous citric acid, sodium citrate anhydrous, sodium benzoate, microcrystalline cellulose, sodium carboxymethylcellulose, xanthan gum, colloidal silica, silicon dioxide, sodium saccharin, mannitol, flavorings
Otitis media, bronchitis, cholecystitis, pneumonia, osteomyelitis, tonsillitis, tonsillitis, sinusitis, periodontitis, pharyngitis, urinary tract infections, skin infections
- urinary tract infection,
- skin and soft tissue infections,
- sepsis, peritonitis, bone and joint infections inflammation of the appendages.
Amoxiclav Hypersensitivity to the drug.
- diarrhea (diarrhea)
- skin redness,
How to accept, acceptance rate and dosage
Amoxiclav: adults and children over 14 years of age on 1 tab. (375 mg) 3 times / day. In severe infections, 1 tab. (625 mg) 3 times / day.
children 7 to 14 years 2 teaspoons (10 ml) suspension of 3 times / day. Children from 1 year to 7 years: 1 teaspoon of suspension 3 times / day.
children under 1 year of 0.75-1.25 ml drops or 1/2 teaspoon suspension of 3 times / day. treatment drug Amoxiclav 5-14 days.
Stored in a dry place inaccessible to children at a temperature not higher than 25 ° C.
After cooking, the slurry must be stored for receiving the inwardly at a temperature of from 2 ° to 8 ° C in a tightly closed vial and used within 7 days.
Amoxicillin, Clavulanic acid
In an application Amoksiklava and indirect anticoagulants there is an increase in prothrombin time. Therefore, this combination is assigned with caution.
In an application Amoksiklava with allopurinol increases the risk of side effects such as rash.
In an application Amoxiclav enhances the toxicity of methotrexate.
The combination of amoxicillin and rifampicin antagonistic (celebrated mutual weakening of the antibacterial action).
Amoxiclav should not be used simultaneously with bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides due to a possible decrease in the effectiveness Amoksiklava.
With simultaneous use of Amoxiclav reduces the effectiveness of oral contraceptives.
Precautions prescribers Amoksiklav patients prone to allergic reactions, as well as in patients with known hypersensitivity to cephalosporin antibiotics, since there is a risk of cross-reactivity.
Simultaneous treatment with drugs to reduce blood clotting leads to increased action of the latter. The drug reduces the effect of aminoglycoside antibiotics. Prolonged treatment is necessary to monitor the state functions of blood, liver and kidneys.
About overdose there is no message. Symptoms: abdominal pain, diarrhea, vomiting; may also agitation, insomnia, dizziness; in some cases – seizures. Treatment: In case recent dosing (less than 4 hours) is necessary to assign a gastric lavage and activated charcoal to reduce absorption of the drug; if necessary symptomatic treatment. Effective hemodialysis.