For adults on prescription
bicalutamide 150 mg.
corn starch 107 mg
Croscarmellose sodium 19.5 mg,
Lactose monohydrate 132.9 mg
povidone 7.6 mg,
3 mg of sodium stearyl fumarate.
Composition of coating film:
Opadry II White 12 mg.
Prostate cancer – as part of combination therapy with GnRH analogue or surgical castration.
- Simultaneous treatment with terfenadine, astemizole, cisapride;
- children’s age;
- Hypersensitivity to bicalutamide;
- does not prescribe female patients.
From endocrine system: hot flashes, breast tenderness and gynecomastia, decreased libido.
From the digestive system: abdominal pain, diarrhea, nausea, vomiting, increased levels of transaminases, jaundice, cholestasis.
CNS: possible asthenia, depression.
Dermatological reactions: alopecia, hair growth reduction, itching, dry skin.
How to accept, acceptance rate and dosage
Individual, depending on indications and treatment regimens.
In a dry place, protected from light at a temperature not higher than 25 ° C
In applying bicalutamide for 28 days in patients receiving midazolam, midazolam AUC increased by 80%.
With simultaneous application of bicalutamide with cyclosporin or calcium channel blockers may potentiation or development of adverse reactions.
Theoretically bicalutamide may increase the concentration in plasma when it is applied simultaneously with inhibitors of hepatic microsomal enzymes which may be accompanied by an increase in the incidence of adverse reactions.
In vitro studies have shown that bicalutamide can displace the coumarin anticoagulant warfarin a number of binding sites to plasma proteins.
With caution in patients with moderate and severe hepatic impairment, as possible accumulation of bicalutamide in the body.
During treatment requires regular monitoring of liver function. In case of severe changes, you must stop taking bicalutamide.
Pregnancy and lactation
Do not appoint female patients.
Cases of overdose have not been described in humans.
There is no specific antidote. Treatment is symptomatic.
Dialysis is not efficient since bicalutamide binds strongly with proteins and excreted by the kidneys in unchanged form. Shows a general supportive treatment and monitoring of vital body functions.