Ferinekt – the preparation of iron.
It represents karboksimaltozatny polynuclear complex of iron (III) hydroxide.
Following parenteral administration of macromolecular complex is captured by the reticulo-endothelial system and decomposes into iron and karboksimaltozu.
Iron into the bloodstream, where it binds to the transport protein transferrin.
Iron in complex with transferrin transferred to the cells of the body, where it is used for the synthesis of hemoglobin, myoglobin and large amounts of enzymes or accumulates as ferritin.
Vifor (International) Inc., Switzerland
Adults are prescribed by a doctor
sodium hydroxide / hydrochloric acid to pH 5,0-7,0;
Water for injections to 1 mL.
Iron deficiency anemia is when oral iron preparations are ineffective or may not be used.
The diagnosis should be confirmed by laboratory tests.
- anemias not associated with iron deficiency;
- the symptoms of iron overload or disturbances of iron utilization;
- I trimester of pregnancy;
- Children under 14 years;
- hypersensitivity to the drug Ferinekt.
Precautions should be used when the drug hepatic insufficiency, acute or chronic infectious diseases (possibly inhibition of erythropoiesis), bronchial asthma, eczema, atopic allergy.
Allergic reactions: often – rash; infrequently – urticaria, hypersensitivity reactions including anaphylactoid reactions.
From the nervous system: often – headache; dizziness; rarely – paresthesia.
Cardio-vascular system: Infrequent – lowering blood pressure, “tides” of blood to the skin.
The respiratory system: rarely – shortness of breath.
From the digestive system: often – nausea, stomach pain, diarrhea, constipation; infrequently – a change of taste, vomiting, dyspepsia, flatulence.
On the part of the bone-myshchenoy system: rarely – myalgia, back pain, arthralgia.
General reactions: rarely – fever, fatigue, chest pain, chills, malaise, peripheral edema.
Local reactions: often – reactions at the injection site.
From the laboratory parameters: often – increase in serum ALT, transient decrease in serum phosphate content of blood; rarely – increase of activity ACT, GGT, LDH.
How to accept, acceptance rate and dosage
B / – bolus or infusion, and by injection into the venous portion of the dialysis system
Before opening the need to examine the vials for the presence of possible sediment and damage. You can only use a homogeneous clear solution.
It is impossible to assign a drip drug 20 ml Ferinekt more than 1 time per week.
It may be administered in / drip in a maximum single dose of 20 mL Ferinekt preparation (1000 mg iron), which should not exceed 0.3 ml Ferinekt drug (15 mg of iron) per 1 kg of body weight or the counted cumulative dose.
Ferinekt may be administered in / jet, a maximum single dose of 4 ml (200 mg of iron) per day but not more than 3 times per week.
Cumulative dose in mg of elemental iron required to restore the level of hemoglobin (Hb) and replenishment of iron stores is calculated individually in accordance with the general lack of iron in the body by the formula:
Cumulative iron deficiency [mg] = body weight [kg] × (target Hb * – actual Hb) [g / dl] ** × 2,4 *** + spare depot iron [mg] ****
* Target Hb with a body weight less than 35 kg = 13 g / dL (or 8.1 mmol / l). Target Hb at 35 kg body weight and more = 15 g / dL (or 9.3 mmol / l).
** To convert Hb [mM] in Hb [g / dL]: multiply Hb [mM] by a factor of 1,61145
*** The coefficient 2,4 = 0,0034 × 0,07 × 10000 where:
0.0034 – hemoglobin iron is approximately equal to 0,34%;
0.07 – blood volume is approximately 7% of body weight;
10000 – the conversion factor: 1 g / dL = 10000 mg / l
**** iron deposited at a body weight less than 35 kg = 15 mg / kg body weight; iron deposited at a body weight of 35 kg and more = 500 mg.
For patients ≤66 kg: calculated cumulative dose of iron should be rounded down to the nearest 100 mg.
For patients > 66 kg: calculated cumulative iron dose must be rounded up to the nearest 100 mg
With the consequent need to maintain a target level of Hb and other laboratory indicators of iron stores within the permissible range may Ferinekt continued treatment with a minimum maintenance dose.
The maximum tolerated single dose
Adequate cumulative dose must be calculated for each patient individually and must not exceed calculated.
At a temperature of not higher than 30 ° C, in the original package (do not freeze)
Any parenteral iron preparations should not be administered concurrently with iron dosage forms for oral administration, as it reduces the absorption of iron from the gastrointestinal tract.
Symptoms: Ferinekt in excess of the needs of the body, can cause iron overload, manifested symptoms of hemosiderosis.
Determination of iron metabolism as the serum ferritin and transferrin saturation percentage may aid in the diagnosis of excessive iron deposits in the body.
Treatment: symptomatic therapy. If necessary, it can be used chelated compound (e.g., deferoxamine).