Gialurom 15 mg/ml 2 ml syringe 1 pc.

A solution for intraarticular administration GIALUROM – 1.5% sodium hyaluronate solution in disposable syringes of 2 ml is a sterile viscoelastic solution of sodium hyaluronate.

Sodium hyaluronate obtainable by fermentation. Sodium hyaluronate is a polysaccharide GIALUROM identical human, consists of repeating disaccharide units of N-atsetilglikozamina and sodium glucuronate having a molecular weight greater than 2,400,000 Da. Sodium hyaluronate is present everywhere in the human body and is present in high concentrations in the tissues, such as vitreous humor, synovial fluid, umbilical cord and dermis.

The sodium hyaluronate synovial fluid acts as a lubricant and shock absorber, which promotes normal movement without pain. When disease such as arthritis, viscoelasticity of the synovial fluid is reduced, so that significantly increases the mechanical load on the joint and enhanced destruction of articular cartilage, and the restriction is manifested pain at movement in joints.

Lubricating and cushioning effect of the drug alleviate pain and improve joint mobility with intra-articular administration. These effects last for more than 6 months after a single treatment.

Active substance:
Hyaluronic acid

Manufacturer

K.O.Romfarm Company SRL Romania

Composition

Active ingredients:

sodium hyaluronate,

sodium chloride,

water for injections

Indications

GIALUROM solution was used as the viscoelastic agent for substitution of the synovial fluid for pain caused by degenerative diseases synovial joints, such as osteoarthritis or osteoarthrosis. By its action GIALUROM drug serves as a lubricant and a mechanical support for the patient’s joint. GIALUROM solution was introduced into human joints:

• for pain and limited mobility caused by degenerative-dystrophic and traumatic changes of the knee, hip and other synovial joints;


• for temporary replacement or supplement of synovial fluid;


• in the treatment of patients with active lifestyle and regularly of loading the affected joint.

Contraindications

• idiosyncrasy (including a history of hypersensitivity) components GIALUROM solution;
• for infected wounds, abrasions in the joint;
• infectious diseases of the joints;
• the known systemic bleeding disorders. GIALUROM may contain traces of bacterial proteins and is contraindicated in patients with known hypersensitivity appropriate.

Side effects

Sodium hyaluronate is characterized by excellent tolerability.

Occurrence of local secondary effects such as pain, feeling of warmth, redness and swelling may occur at the joint, into which the drug (superposition joint ice for five – ten minutes to remove all such phenomena).

allergic reactions may occur very rarely.

With intraarticular injection there are minimal risks of infection and bleeding.

How to accept, acceptance rate and dosage

GIALUROM injections made by specialist doctors.

GIALUROM solution is only intended for intra-articular application. Do not use intravenously. Introduction of sodium hyaluronate is carried out at room temperature. Injected volume depends on the size of the joint, but does not exceed 2 ml into the knee joint and other large joints, or 1 ml for small joints. The doctor is responsible for the establishment of the applicable amount and have to make sure that the joint is not overloaded.

GIALUROM solution is introduced into the cavity of the joint once a week for 3 consecutive weeks. The simultaneous treatment of multiple joints. it is impossible to carry out a repeated cycle of treatment earlier than 6 months for the same joint. Before using the product GIALUROM, fluid accumulation in the joint should be removed by sucking syringe.

GIALUROM solution discharged in a pre-filled syringe, which is not necessary to dilute the contents. The drug is sterile and should be used immediately after opening the package. The drug is intended for single use only. GIALUROM should be carefully introduced into the joint cavity, carefully following the introduction scheme. The introduction is an aseptic procedure, therefore, observe proper precautions. Ready sterile syringe is removed from its case, the cap is removed and then put on a sterile needle, which is fixed by a slight twist. Before the introduction is necessary to remove air from the syringe.

Active substance

Hyaluronic acid