“Combined drug. Heparin is a direct anticoagulant, when applied externally it has antithrombotic, antiexudative and moderate anti-inflammatory effect, promotes the regeneration of connective tissue, prevents blood coagulation in hemorrhoids.
Prednisolone is a glucocorticoid that has anti-inflammatory, anti-exudative and anti-allergic effects; reduces inflammation and related sensations (itching, burning, pain) in the anorectal region.
Polidocanol has a local anesthetic effect and provides hardening of hemorrhoids. “
1 g of the drug contains:
Sodium heparin – 65 ME;
(1 IU of sodium heparin – anticoagulant activity, corresponds to the activity of 0.0077 mg of the II International Standard of Heparin (WHO))
Prednisolone acetate – 2.233 mg;
Lauromacrogol 600 – 30.00 mg.
Colloidal silicon dioxide.
External and internal hemorrhoids.
Thrombophlebitis of hemorrhoidal veins of the anus.
Fistulas, eczema, and itching in the anus.
preparation for surgical intervention in the anorectal region.
as part of the complex therapy of thrombosed or operated hemorrhoids.
- hypersensitivity to drug components;
- bacterial, viral, fungal skin lesions;
- tumors of the skin (anorectal zone);
- predisposition to bleeding;
- reactions to vaccinations;
- I trimester of pregnancy.
Systemic reactions: allergic reactions, skin flushing.
With prolonged use and / or when applied to large surfaces, systemic side effects are possible: slowing down of the regeneration of cracks, edema.
How to take, course of administration and dosage
Outwardly, the ointment is applied to the affected areas with a thin layer 2-4 times a day; after the disappearance of painful sensations – 1 time per day for 7 days.
For the introduction of the ointment, the attached screw-on tip is used, which is inserted into the rectal cavity, and a small amount of the ointment is squeezed out by lightly pressing the tube.
After adsorption, plasma protein binding is 95%.
From tissues it is released slowly with a half-period of about 1 hour. 50% of the active substance remains on the skin after administration. The release rate depends on the dose.
After absorption, it is metabolized in the liver (partly by the enzyme hepatic heparinase) and in the reticuloendothelial system.
20-50% is excreted in the urine unchanged and partially as uroheparin, which has a weak anticoagulant effect.
The release is dose dependent (lower doses have a shorter plasma half life).
Prednisolone is metabolized in the liver after absorption.
About 1% is excreted in the urine unchanged.
Biological T1 / 2 is 18-36 hours, and T1 / 2 from plasma is 115-212 minutes.
20 g of ointment in an aluminum tube sealed with a plastic screw cap.
The opening of the tube is protected by an aluminum membrane.
The cap is a monolithic structure that includes a membrane piercing device.
The tube together with the tip and instructions for use in a cardboard box.
As with all other corticosteroids, care should be taken not to use the drug in large quantities or for a long time.
The drug does not affect the ability to drive vehicles and potentially dangerous mechanisms.
Store at temperatures between 15 and 25 ° C.
Keep out of the reach of children!