Hydroxyprogesterone – an analogue of the corpus luteum hormone (progesterone). Progesterone is chemically different from that at position 17 comprises the residue of caproic acid. Being ether hydroxyprogesterone, progesterone is metabolized slower (providing more prolonged effect). After single i / m of an oil solution of its effect lasts between 7 to 14 days. Biological properties similar to progesterone. By binding to receptors on the surface of cells Organs, it enters the nucleus, where it activates DNA promotes RNA synthesis.
It facilitates the transition from the phase of the mucous membrane of the uterus proliferation, called follicular hormone into secretory, and after fertilization creates the necessary conditions for the development and implantation of a fertilized egg. Decreases Uterine contractility and excitability of muscle and fallopian tubes, stimulates the development of breast end elements.
1 ampoule with 1 ml solution for injection in the peach or olive oil contains hydroxyprogesterone capronate 125 mg (12.5%) mg.
Conditions associated with corpus luteum insufficiency:
- menacing and began miscarriage (prevention and treatment),
- amenorrhea (primary and secondary),
- dysfunctional uterine bleeding.
- liver failure,
- breast cancer and genital organs,
- a tendency to thrombosis.
C care. Diseases of the cardiovascular system, hypertension, chronic renal failure, diabetes, asthma, epilepsy, migraine, depression; hyperlipoproteinemia, ectopic pregnancy, lactation.
From the nervous system: drowsiness, headache, depression, lethargy, dysphoria.
From the digestive system: cholestatic hepatitis, nausea, vomiting, decreased appetite, calculous cholecystitis.
With the genitourinary system: reduced libido, reduced menstrual cycle, intermediate bleeding.
From the senses: blurred vision.
From the CCC: increased blood pressure, edema, thromboembolism (including pulmonary embolism and cerebral vessels), thrombophlebitis, thrombosis, retinal vein.
From endocrine system: galactorrhea, alopecia, weight gain, increased pain and tension of the mammary glands; hirsutism. Allergic reactions.
Local reactions: pain at the injection site.
How to accept, acceptance rate and dosage
For the purpose of prevention and treatment of threatened miscarriage and the beginning of 0.125-0.25 g administered (2.1 ml of 12.5% solution), 1 time per week. Used only in the first half of pregnancy.
When amenorrhea (primary, secondary) is assigned immediately after discontinuation of estrogen on PM 0.25 g, once or in 2 administration.
For treatment of dysfunctional uterine krovotecheniypreparat less convenient than progesterone, since its effect is slow, but they can be used to normalize the series: 0.0625-0.125 g (0.5-1 ml of 12.5% solution) at 20-22 day cycle.
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