FarmGruppa: Complex B vitamins
Pharmacological action: KompligamV – combination product containing B vitamins and lidocaine
Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nerves and musculoskeletal system. They do not apply to removal of deficiency states, and in high doses, have analgesic properties, contribute to increased blood flow, and normalize the nervous system and the process of hematopoiesis (vitamin B12).
Thiamine (B1) plays a key role in the processes of carbohydrate metabolism, of crucial importance in nervous tissue of metabolic processes, and in the Krebs cycle with subsequent participation in the synthesis of TPP (thiamine pyrophosphate), and ATP (adenosine triphosphate).
Pyridoxine (B6) is involved in the metabolism of proteins, and partly in the metabolism of carbohydrates and fats.
Physiological function of both vitamins (B1, B6) is a potentiation of each other, which manifests itself in a positive impact on the nervous, neuromuscular and cardiovascular systems.
Cyanocobalamin (B12) involved in the synthesis of the myelin sheath, stimulates hematopoiesis, reduces pain associated with a lesion of the peripheral nervous system stimulates nucleic exchange via folate activation.
Lidocaine – local anesthetic, causing all kinds of local anesthesia
Pharmacokinetics Following intramuscular administration KompligamV thiamine rapidly absorbed from the injection site and enters the blood (484 ng / ml after 15 minutes on the first day of dosing 50 mg) and unevenly distributed in the body when its content in leukocytes of 15% erythrocytes 75% and blood plasma of 10%. In the absence of significant reserves of the vitamin in the body, it must be ingested daily.
Thiamine penetrates the blood-brain and the placental barrier, it is found in breast milk. Thiamine is excreted in the urine through the alpha phase of 0.15 hours, the beta phase – after 1 hour, and in the terminal phase – for 2 days. The major metabolites are tiaminkarbonovaya acid Pyramin and some unidentified metabolites. Of all the vitamins, thiamine in the body is stored in the smallest quantities. An adult human contains about 30 mg of thiamine as 80% in the form of thiamine pyrophosphate, thiamine triphosphate 10% and the remainder in the form of thiamine monophosphate.
After intramuscular injection of pyridoxine is rapidly absorbed into the bloodstream and distributed in the body, acting as a coenzyme after phosphorylation group CH2OH in the fifth position. About 80% of the vitamin bound to plasma proteins. Pyridoxine is distributed throughout the body, crosses the placenta, it is found in breast milk.
Deposited in the liver and is oxidized to 4-pyridoxine acid, which is excreted in the urine, a maximum 2-5 hours after absorption. The human body contains 40-150 mg of vitamin B6 daily its elimination rate is about 1.7 – 3.6 mg at a rate of replenishment of 2,2 – 2,4%
1 mL contains thiamine hydrochloride (Vit. B1) 50 mg, pyridoxine hydrochloride (Vit. B6) 50 mg Cyanocobalamin (Vit. B12) 500 mcg, lidocaine hydrochloride 10 mg,
Excipients: benzyl alcohol, sodium polyphosphate, sodium tripolyphosphate, potassium hexacyanoferrate, sodium hydroxide (1M solution), water d / and
Sciatica, neuralgia of the ternary nerve from lumbago, from neuritis, osteochondrosis, from sciatica
For the pathogenetic and symptomatic treatment of diseases and syndromes of the nervous system of different origin:
- neuropathy and polyneuropathy (diabetic, alcoholic and other);
- neuritis and polyneuritis, including optic neuritis;
- peripheral paresis, including facial nerve;
- neuralgia, including trigeminal nerve and intercostal nerves;
- pain (radicular, myalgia);
- nocturnal muscle cramps, particularly in older age groups;
- plexopathy, ganglionitis (including herpes zoster);
- neurological manifestations of osteochondrosis (radiculopathy, lumbar ischialgia, musculo-tonic syndromes).
- severe and acute form of decompensated congestive heart failure;
- children’s age (due to lack of research);
- hypersensitivity to the drug.
Allergic reactions: skin reactions such as pruritus, urticaria; rarely – hypersensitivity reactions to the drug, including rash, difficulty breathing, angioneurotic edema, anaphylactic shock.
Other: in some cases – increased perspiration, tachycardia, acne
How to accept, acceptance rate and dosage
In marked pain syndrome treatment is advisable to start with the / m (deep) 2 mL of formulation daily for 5-10 days with the transition hereinafter either the intake or at a rare of injection – 2-3 times a week 2-3 weeks.
In the dark place at a temperature of 2-8 ° C
Pyridoxine, thiamine, cyanocobalamin, lidocaine
Pyridoxine is not administered with levodopa, as the weakened effect of the latter. Taking into account the presence in the formulation of lidocaine, in the case of the additional use of epinephrine and norepinephrine, may increase the side effects on the heart. In case of overdose of local anesthetics can not be further applied epinephrine and norepinephrine.
In the case of very rapid introduction of the drug may develop systemic reactions (dizziness, arrhythmia, seizures).
Pregnancy and lactation
Do not use the drug in Kompligam during pregnancy and lactation (breastfeeding).