Milgamma – metabolic, neuroprotective, analgesic.
Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative nerve diseases and musculoskeletal system. Thiamine plays a key role in the metabolism of carbohydrates, as well as in the Krebs cycle, followed by participation in the synthesis of thiamine pyrophosphate and ATP. Pyridoxine is involved in protein metabolism, and partly – in the metabolism of carbohydrates and fats.
Physiological function of both vitamins is a potentiation of each other, which manifests itself in a positive effect on the nervous and neuromuscular systems. Cyanocobalamin is involved in the synthesis of the myelin sheath, reduces pain associated with a lesion of the peripheral nervous system stimulates nucleic exchange via folate activation. Lidocaine – local anesthetic, causing all kinds of local anesthesia: terminal, infiltration, and conductors.
After the / m of thiamine is rapidly absorbed from the injection site and enters the blood (484 ng / ml after 15 minutes on the first day of dosing 50 mg) and unevenly distributed in the body when its content in leukocytes – 15%, erythrocytes – 75% and plasma – 10%. In the absence of significant reserves of the vitamin in the body, it must be ingested daily. Thiamine penetrates the blood-brain and the placental barrier and is found in breast milk. Thiamine is excreted in the urine through the alpha phase 0,15 h in the beta phase – after 1 h, and in the terminal phase – for 2 days.
major metabolites are : tiaminkarbonovaya acid Pyramin and some unidentified metabolites. Of all the vitamins, thiamine in the body is stored in the smallest quantities. An adult human contains about 30 mg of thiamine as thiamine pyrophosphate (80%), thiamine triphosphate (10%) and the remainder in the form of thiamine monophosphate.
After intramuscular injection of pyridoxine is rapidly absorbed into the bloodstream and distributed in the body, acting as a coenzyme after phosphorylation CH2OH group in the 5-position. About 80% of the vitamin bound to plasma proteins.
Pyridoxine is distributed throughout the body, to cross the placenta, and is found in human milk, it is deposited in the liver and is oxidized to 4-pyridoxine acid, which is excreted in the urine after a maximum 2-5 hours after absorption. The human body contains 40-150 mg of vitamin B6 and its daily elimination rate of about 1,7-3,6 mg at 2.2-2.4% fill rate.
Solyufarm Farmatsoytishe Ertsoygnisse GmbH, Germany
1 ml solution contains:
thiamine chloride hydrochloride, 50 mg,
pyridoxine hydrochloride 50 mg
Cyanocobalamin 0.5 mg,
lidocaine hydrochloride 10 mg
– benzyl alcohol,
water for injections.
Sciatica, from lumbago, neuralgia threefold nerve from sciatica, degenerative disc disease from, from neuritis
As symptomatic and pathogenetic agents in the adjuvant therapy of diseases and nervous system syndromes of different origin:
paresis of the facial nerve,
ganglionitis (including herpes zoster),
neuropathy (diabetic, alcoholic, etc.),
nocturnal muscle cramps, particularly in older age groups,
neurological manifestations of osteochondrosis: radiculopathy, lumbar ischialgia, musculo-tonic syndromes.
Decompensated heart failure.
Increased individual sensitivity to the drug.
Children’s age, due to lack of data.
In some cases it may be sweating, tachycardia, there is acne.
Skin reactions are described in the form of itching, urticaria; shortness of breath, angioneurotic edema, anaphylactic shock.
How to accept, acceptance rate and dosage
In cases of severe pain syndrome for the rapid achievement of a high level of drug in the blood treatment is advisable to start with 2 ml daily for 5-10 days. Subsequently after decrease of pain and in mild forms of the disease or a therapy proceeds dosage form for oral administration (e.g. drug Milgamma® kompozitum) or more rare injection (2-3 times per week for 2-3 weeks), with a possible continuation of therapy dosage form for oral administration. Recommended weekly monitoring by a doctor therapy.
Going to therapy dosage form for oral administration is recommended in most soon as possible.
The drug should be stored at 2- 8 C, zamorzhivat Not!
Pyridoxine, thiamine, cyanocobalamin, lidocaine
Thiamine completely destroyed in solutions containing sulfites. Other vitamins are inactivated in the presence of decomposition products of vitamins of group B. Levodopa reduces the effect of pyridoxine. Possible interactions with drug cycloserine, D-penicillamine, epinephrine, norepinephrine, sulfonamides, which leads to a decrease in the effect of pyridoxine.
Thiamine is incompatible with oxidizing agents, mercury chloride, iodide, carbonate, acetate, tannic acid, iron ammonium citrate, as well as phenobarbital, riboflavin, benzylpenicillin, dextrose and sodium metabisulphite. Copper accelerates the destruction of thiamine. Thiamine loses its effect by increasing pH (more than 3).