The exact mechanism of action of allergen during allergen specific immunotherapy (ASIT) not completely clear.
The following biological change is proved that the appearance of specific antibodies (IgG4), playing the role of “blocking antibodies”; reduction of the specific IgE in the plasma for a prolonged period; decrease the reactivity of cells involved in allergic reactions; increased activity of interaction between T cells and Th1 and Th2 even Th0, resulting in a positive change in cytokine production (reduction of IL-4 and increasing IFN-gamma) regulating the production of IgE.
Additionally, Asit elicits an immune response that keeps immunobiological memory for long periods. Efficiency Asit higher in those cases where the treatment is started in the early stages of the disease.
Grass pollen allergens
Active substance: allergen extract from a mixture of grass pollen (cocksfoot, common spikelet bayberry, Lolium perenne, Poa pratense, timothy grass) in equal proportions, TS 100 and TS 300;
Excipients: Microcrystalline cellulose – 12.5 mg Sodium croscarmellose – 2.5 mg Colloidal silicon dioxide – 0.5 mg magnesium stearate – 0.7 mg lactose monohydrate – to 100 mg.
Allergen-specific immunotherapy (ASIT) patients with an allergic reaction of type 1 (IgE-mediated), manifested as rhinitis or rinokonyuktivita having sensitization to pollen meadow gangway (cocksfoot, spikelet fragrant vulgaris, Lolium perenne, Poa pratense, timothy grass), confirmed positive results in cutaneous test and / or a high content of specific lgE. Immunotherapy may be performed in adults and children 5 years of age.
- Hypersensitivity to any of the excipients;
- beta-blocker therapy;
- uncontrolled or severe asthma (forced expiratory volume in less than 70%);
- severe immunodeficiencies and autoimmune diseases; oncological diseases;
- inflammatory diseases of the oral mucosa (erosive-ulcerous form planus, ulceration, mycosis);
- nasledetvennaya galactose intolerance, the Lapp lactase deficiency, malabsorption of glucose and galactose.
Immune system: allergic reactions.
On the part of the central nervous system and peripheral nervous system: headache, dizziness, change in taste, paresthesia.
On the part of the organ of vision: conjunctivitis, hyperemia.
On the part of the organ of hearing: itchy ears, ear congestion.
The respiratory system: throat irritation, shortness of breath, edema, rhinitis symptoms, sore throat, cough, dyspnea, dysphonia.
On the part of the gastrointestinal tract: itching, swelling, inflammation, numbness, tingling in the mouth, increased salivation, dry mouth, lips, vesicular lesions in the mouth, on the lips, glossodiniya, gastrointestinal disorders, inflammation of the gastrointestinal tract.
Skin and subcutaneous tissue disorders: facial swelling, pruritus, urticaria, angioedema, eczema.
General disorders: fatigue, anxiety.
How to accept, acceptance rate and dosage
drug treatment should be allergist. In the case of the drug in pediatric practice, the physician must have relevant experience in treating children.
It is recommended to take the first pill under the supervision of a physician to monitor the patient for 30 minutes. Treatment should begin within 4 months prior to the expected flowering season continues throughout the pollination season and stop with its end.
The drug is recommended to take in the morning on an empty stomach. The tablet must be placed under the tongue and hold until complete dissolution (for at least 1 minute) and then swallowed. Avoid interruptions in taking the drug. Ne necessary to increase the dose of the drug after skipping.
If you pass the reception of the drug is less than 7 days, it is recommended to resume taking the drug at the same dose, which was interrupted treatment, and follow the recommended scheme. At long pass (more than 7 days) is necessary to consult with your doctor.
Keep out of reach for children, at a temperature not higher than 25 C.
Grass pollen allergens
At surgical operations in the oral pn (including removing tubes) should be discontinued before full treatment therapy (at least for 7 days). In case of severe allergic reactions, your doctor may recommend acceptance of epinephrine.
It should be taken into account that in patients receiving tricyclic antidepressants, monoamine oxidase inhibitors, increases the risk of side effects in its administration until death. Clinical experience with simultaneous vaccination and treatment with no.
Vaccination can be done only after consultation with your doctor. The drug has no effect on the ability to drive vehicles and mechanisms.