Ornithine provides detoxification, gipoazotemicheskoe, hepatoprotective, gipoammoniemicheskoe action. Utilizes ammonium groups in the synthesis of urea (ornithine cycle). Reduces the concentration of ammonia in plasma, contributes to the normalization of blood acid-base state, thus improves the solubility of the salts and accelerates their isolation from urine. Ornithine, reinforcing ornithine cycle accelerates the recycling of organic complexes of nitrogen to urea synthesis and reduces uric acid. Ornithine reducing uric acid synthesis delay beginning the formation of kidney stones. Also, ornithine stimulates insulin and growth hormone. When administered ornithine aspartate dissociates into its constituent components (ornithine and aspartate), which are absorbed in the small intestine by active transport across the intestinal epithelium. Excreted in the urine after urea formation cycle.
Silymarin – means comprising flavanoidnyh complex compounds derived from milk thistle. Silymarin has regenerative, detoxication, anti-inflammatory and hepatoprotective effect. The mechanism of action of the drug associated with its ability to activate the synthesis of essential proteins and phospholipids in hepatocytes, due to the stimulation of RNA polymerase. Silymarin has a marked antioxidant effect, helps protect cells from the negative effects of free radicals and peroxy compounds. The antioxidant effect of the preparation is carried out by the presence in the molecules of flavonoids phenolic structure, which participates in the binding of free radicals. Thus, the inhibition of lipid peroxidation in hepatocytes, which contributes to the preservation of cellular structures and their speedy recovery. The drug not only reduces the rate of formation of malonaldehyde, but also regulates the absorption of oxygen by cells. The preparation enhances the detoxication activity of the liver by increasing concentrations of glutathione. When alcohol intoxication medication reduces the formation of acetaldehyde. Silymarin has a pronounced membrane stabilizing effect due to the biochemical interactions with cell membranes preparation prevents loss of substances contained in the cell and improves metabolic processes.
Artichoke has a choleretic, hepatoprotective and diuretic effects. Also contributes umenshensheniyu urea level in the blood serum. The drug increases the ability of hepatocytes to produce co-enzymes, which improves the exchange of cholesterol, lipids and metabolism of ketone bodies. When concomitant antibiotic acts on the kidney parenchyma and liver as a detoxication agent. Inulin and vitamins of group B (B 2 , B 1 ), included in the list of bioactive substances artichoke, normalize metabolic processes in the body. The drug helps cleanse the body of toxins, including nitro compounds, heavy metal salts and alkaloids.
Novator Pharma, UK
Active ingredients: 200 mg of ornithine; Silymarin 70 mg; artichoke 200 mg.
The drug used in treatment of liver diseases, the gall bladder and kidney of various etiologies, including:
- chronic viral hepatitis. Treatment of patients with sub-acute, persistent and chronic active form of viral hepatitis;
- the period of rehabilitation after acute forms of viral hepatitis;
- liver disease associated with impaired lipid metabolism, including steatosis (steatosis) and fatty liver;
- cirrhosis of various etiology;
- the drug is also used in the treatment of patients with impaired lipidnoholesterinovogo exchange;
- hepatic encephalopathy;
- acute and chronic cholecystitis, cholangitis, hypokinetic embodiment biliary dyskinesia;
- the drug is also used in the treatment of patients with kidney disease.
Medicinal liver and reception period preparations having hepatotoxic properties:
- halogenated hydrocarbons and poisoning by heavy metals;
- poisoning organic solvents;
- liver injury associated with the consumption of alcohol, including in patients with chronic alcoholism and in acute poisoning with ethyl alcohol.
Hypersensitivity to the drug. Renal failure (creatinine at a level in the plasma for more than 3 mg / 100 ml).
Rarely skin reactions, and in some cases nausea and vomiting.
How to accept, acceptance rate and dosage
When the free use of the consumer, it is necessary to respect the rules that are specified on the packaging. If the drug is assigned a doctor, there may be a change in dosage: one tablet 1-2 times daily, orally, after meals
Store at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Cm. On the package.