The action of progesterone on the one hand, is based on blocking estrogen recipes resulting in improved absorption of the tissue fluid decreases compression of milk ducts; other – blocking prolactin receptors in breast tissue, which leads to a reduction laktopoeza. Thus, the local use of the product, creating a high concentration of progesterone in the application zone, does not have systemic action and avoids unwanted side effects.
The mechanism of action of Prozhestozhelya based on enhancing progesterone concentration in breast tissue. The active component of the drug is progesterone.
Progesterone reduces the expression of estrogen receptors in breast tissue and also reduces the local level of active estrogens by stimulating the production of enzymes (17beta-hydroxysteroid and estronsulfotransferazy) oxidizing estradiol less active estrone, and then tying posleny transforming it into an inactive estronasulfat. Thus, progesterone limits the proliferative effect of estrogens on the breast tissue.
Also natriydiureticheskim progesterone has little effect due to inhibition of tubular reabsorption and increased filtration cell, thereby preventing fluid retention during transformation secretory mammary glandular component and, consequently, the development of pain (mastalgia or mastodynia). Along with this, the transdermal route of administration of progestogen can also affect the condition of the glandular epithelium and vasculature, thereby reducing the permeability of the capillaries and, hence, decreases the degree of swelling of the breast tissue and mastalgia symptoms disappear.
When applying the method transdermal Prozhestozhel reaches mammary tissue without being destroyed in the liver and without exerting adverse systemic effects on the body. Investigation of serum prolactin, Estrada Iola and progesterone in the treatment of Prozhestozhelem has shown that an hour after applying the product when there is its maximum absorption in tissue, hormone levels virtually unchanged.
Absorption of progesterone in the cutaneous application is about 10% of the dose. Cutaneous applications for breast region allow, on the one hand to reduce the applied dose of the drug, and on the other – to create a high concentration range (10 times higher than in the systemic circulation). A second drug is metabolized in the liver to form conjugates with glucuronic acid and sulfuric acid. Also participates in the metabolism of the isozyme CYP2C19. Excreted by the kidneys – 50-60%, with bile – more than 10%. Metabolites, kidneys displayed varies depending on the luteal phase.
Bezen Menyufekchuring Beldzhium, Belgium
Adults are prescribed by a doctor, for women, nursing mothers
Composition per 100 g:
The active ingredient is:
Natural progesterone is micronized – 1 Year
octyldodecanol, carbomer 980,
macrogol glitserilgidroksistearat (polioksilgidrogenizirovannoe castor oil)
ethanol, based on absolute ethanol 96% (v / v)
– diffuse fibrocystic breasts
– Individual hypersensitivity to any component of the drug
– nodular fibrocystic breasts
– Tumors (tumor formation) of the mammary glands of unknown etiology
-. Pregnancy (II and III trimesters)
– Breast cancer and genital organs (as monotherapy).
Warning: vaginal bleeding of unknown etiology; porphyria; epilepsy; migraine; depression; giperlipoproteinemiya; liver failure; renal failure; bronchial asthma; ectopic pregnancy; abortion in progress; tendency to thrombosis, acute forms of phlebitis or tromboemboldicheskih diseases; arterial hypertension; diabetes.
Only extremely rare: swelling of the lips and neck, fever, headache, nausea, breast tenderness, “hot” hot flushes, metrorrhagia; decreased libido.
With increased sensitivity to the drug components – erythema at the site of gel application.
How to accept, acceptance rate and dosage
1 should be applied appliqué gel Prozhestozhel 1% (2.5 g gel; contains 0.025 g of progesterone) to the skin of breast applicator-dispenser until complete absorption 1-2 times daily or in 2-phase (from 16 to 25 day) of the menstrual cycle.
The course of treatment up to 3 cycles.
Repeated treatment may be appointed only after consultation with your doctor.
At temperatures above 25 ° C.
Action Prozhestozhelya can be intensified against the backdrop konratseptsii combined hormonal therapy.
Prozhestozhel can be administered at mastodynia associated with taking oral contraceptives, puberty, premenopause, premenstrual syndrome.
The preparation should be applied onto breast skin applicator-dispenser, without rubbing or massaging the mammary gland.
Avoid direct sunlight after applying the cream.
Pregnancy and lactation
There is insufficient experience with the Prozhestozhelya during pregnancy.
Use of the drug during pregnancy and lactation is possible only when the intended benefits to the mother outweighs the potential risk to the fetus and child.
Due to low systemic arbsorbtsiey overdose unlikely.