Relief Advance 200 mg/g for Rectal and External Use 25 g

Indication

Local anesthetic for hemorrhoids, anal fissures, after proctological surgeries, during diagnostic procedures.

Method of application and doses

The medication should be applied after hygiene procedures.
Remove the protective cap from the applicator. Attach the applicator to the tube and squeeze out a small amount of ointment to lubricate the applicator. The ointment is carefully applied through the applicator to the affected areas outside or inside the rectum up to 4 times a day in the morning, evening, and after each bowel movement for 7–10 days.
After each use, thoroughly rinse the applicator and place it back in the protective cap.
For children under 12 years, use only as directed by a doctor.
If there is no improvement after treatment, or if symptoms worsen, or new symptoms appear, it is necessary to consult a doctor.
Use the medication according to the indications, method of application, and doses specified in the instructions.

Section: Composition

1 g of ointment contains
Active ingredient: benzocaine 200 mg (20 %).
Excipients: light liquid paraffin 120 mg (12 %), white soft paraffin 647 mg (64.7 %), propylene glycol 20 mg (2 %), methyl paraben 2.4 mg (0.24 %), propyl paraben 0.6 mg (0.06 %), sorbitan stearate 10 mg (1 %).

Homogeneous ointment from white to white color with a yellowish tint, free from foreign inclusions.

Contraindications

Increased individual sensitivity to the components of the drug, thromboembolic disease, granulocytopenia.

Special Instructions

In case of heavy bloody discharge from the rectum or if painful symptoms persist for more than 7 days, it is necessary to consult a proctologist additionally. There have been reports that products containing benzocaine may cause methemoglobinemia. Symptoms such as cyanosis of the skin, lips, and nails, headache, dizziness, shortness of breath (difficulty breathing), weakness, and tachycardia observed during treatment may indicate potentially life-threatening methemoglobinemia, which requires immediate medical attention. To minimize systemic side effects, do not exceed the recommended daily dose unless otherwise prescribed by a doctor. Avoid contact of the medication with latex products (contraceptive diaphragms and condoms) to prevent a decrease in their effectiveness. It is not recommended to apply the medication on damaged skin, as this may increase systemic absorption.

Section: Side Effects

The following side reactions have been reported with the use of products containing benzocaine under various conditions. Since these reactions are listed in reference materials or voluntarily reported by the population in an unspecified quantity, it is not always possible to reliably assess their frequency or establish a causal relationship with the use of the product.
Disorders of the immune system
Allergic reactions.
Disorders of the blood and lymphatic system
Methemoglobinemia.
General disorders and conditions at the site of administration
Erythema, local irritation, swelling, pain, rash at the site of application.
Disorders of the skin and subcutaneous tissue
Allergic dermatitis.
If you experience side effects not listed in the instructions, please inform your doctor.

Section: Overdose

Symptoms of overdose may be related to the pharmacological effects of benzocaine. Its systemic absorption in overdose can manifest as drowsiness, restlessness, agitation, and in severe cases - seizures. Extremely rarely, large doses of benzocaine can cause methemoglobinemia, which is characterized by respiratory disorders and cyanosis. Intravenous administration of methylene blue is a specific treatment for this condition.

Pharmacodynamics

Benzocaine exerts a local anesthetic effect and does not have a systemic effect.