Artra 500 mg + 500 mg 120 coated tablets

Osteoarthritis of peripheral joints and spine

Orally. Adults and children over 15 years: 1 tablet 2 times a day for the first three weeks; 1 tablet once a day for the following weeks and months. A sustained therapeutic effect is achieved with the use of the medication for at least 6 months.

One tablet contains:
Active ingredients:
Substance mixture 1 1185 mg:
Glucosamine hydrochloride 500 mg
Sodium chondroitin sulfate 500 mg
Excipients:
Microcrystalline cellulose 223 mg,
Dicalcium phosphate dihydrate 125 mg,
Sodium croscarmellose 100 mg,
Stearic acid 50 mg,
Magnesium stearate 17 mg
Coating:
Transparent film coating 5 mg
(hydroxypropyl methylcellulose 3.75 mg, triacetin 1.25 mg), Yellow film coating 35 mg (hydroxypropyl methylcellulose 10.85 mg, titanium dioxide 9.41 mg, polydextrose 9.10 mg, talc 2.45 mg, maltodextrin 1.75 mg, medium-chain triglycerides 1.40 mg, yellow iron oxide dye 0.04 mg). 1 - During production, a substance mixture consisting of glucosamine hydrochloride and sodium chondroitin sulfate is used, with an excess of 525.5 mg (calculated on a dry substance basis) and 613.1 mg (calculated on a dry substance basis) respectively.

Biconvex oval tablets coated with a film, from white to white with a yellowish tint, engraved with "ARTRA" on one side of the tablet, with a characteristic odor.

Hypersensitivity, severe kidney function impairment.
With caution:
Bleeding or tendency to bleed, bronchial asthma, diabetes mellitus.
Pregnancy and lactation:
Not recommended during pregnancy and lactation.

Use in Pediatrics
Clinical data on the efficacy and safety of Arthra® in children under 15 years of age are lacking.
Packaging for a course of 3-4 months.

Glucosamine: mild gastrointestinal disturbances may occur (epigastric pain, flatulence, diarrhea, constipation), dizziness, skin allergic reactions. Chondroitin: allergic reactions.

Symptoms: cases of overdose are unknown. Treatment: gastric lavage, symptomatic therapy.

Possible enhancement of the effects of anticoagulants and antiplatelet agents.
Artra® increases the absorption of tetracyclines and reduces the effectiveness of semisynthetic penicillins. The drug is compatible with glucocorticoid medications.

Stimulates the regeneration of cartilage tissue. Glucosamine and sodium chondroitin sulfate participate in the biosynthesis of connective tissue, helping to prevent cartilage destruction and stimulate tissue regeneration. The administration of exogenous glucosamine enhances the production of cartilage matrix and provides nonspecific protection, including from NSAIDs and glucocorticoids (GCs). The drug has a moderate anti-inflammatory effect.

Sodium chondroitin sulfate, whether absorbed in its intact form or as separate components, serves as an additional substrate for the formation of healthy cartilage matrix. It stimulates the formation of proteoglycans and type II collagen, as well as protects the cartilage matrix from enzymatic degradation (by inhibiting the activity of hyaluronidase) and from the damaging effects of free radicals; it maintains the viscosity of synovial fluid, stimulates cartilage repair mechanisms, and suppresses the activity of those enzymes (elastase, hyaluronidase) that degrade cartilage. In the treatment of osteoarthritis, it alleviates disease symptoms and reduces the need for NSAIDs.

The bioavailability of glucosamine when taken orally is 25% (first-pass effect through the liver). It is distributed in tissues: the highest concentrations are found in the liver, kidneys, and articular cartilage. Approximately 30% of the administered dose persists for a long time in bone and muscle tissue.
It is primarily excreted unchanged in urine; partially in feces. T1/2 is 68 hours. The bioavailability of chondroitin sulfate is about 13%.

Artra 500 mg/500 mg - 120 film-coated tablets - is a medication that effectively addresses joint diseases. It contains a combination of two active ingredients - glucosamine and chondroitin sulfate, which aid in the restoration of cartilage tissue and improve joint function. Artra enhances joint mobility, reduces inflammatory processes, and alleviates pain sensations. The medication should be taken strictly as prescribed by a doctor and in accordance with the dosage. Artra is not recommended for those who have allergic reactions to its components, as well as for pregnant and breastfeeding women. The medication does not affect the functioning of systemic organs, which is an additional advantage of its use.