Corilip-Neo 10 pcs rectal suppositories

The drug is indicated for use for preventive and therapeutic purposes in combination therapy for the correction of energy deficiency states, increasing the effectiveness of basic treatment, and accelerating recovery processes in various pathological conditions in children, such as:
• Chronic tissue hypoxia (respiratory distress syndrome, hypoxic damage to the central nervous system, etc.).
• Decreased immunity (prolonged and recurrent course of ARVI, frequently ill children, stress states of the body, including during preventive vaccinations, during infectious epidemics).
• Bacterial and viral infections during the repair (recovery) period, including acute intestinal infections caused by viral and bacterial agents (rotavirus gastroenteritis, calicivirus infection, etc.) and complications of acute intestinal infections (dehydration, toxicosis, dysbiosis, etc.).
• Chronic somatic diseases (congenital heart defects, pneumonia, bronchitis, chronic inflammatory diseases of the urinary system, gastrointestinal dyskinesia, allergic reactions, increased excitability syndrome, asthenic conditions, etc.).
• Chronic intoxications.
• Nutritional disorders (hypotrophy) in children.

The medication is administered rectally. After removing from the packaging, insert the suppository into the rectum following prior bowel evacuation.
Suppositories are prescribed for children under 1 year at a dosage of 1 suppository per day.
The duration of the treatment course is 10 days.
The total duration of treatment is 3-4 courses with an interval of 20 days (3-4 months).

Composition per 1 suppository:
Active ingredients: cocarboxylase hydrochloride - 12.5 mg, riboflavin - 1 mg, thioctic acid (lipoic acid) - 6 mg.
Excipients: solid fat (Vitepsol H15, Vitepsol W35, Kernosol 35, Solid fat produced by "Bunge Loders Croklaan B.V.", Netherlands) - up to a mass of 0.95 g.

Yellow suppositories, torpedo-shaped with possible inclusions of orange-yellow color.

Hypersensitivity reaction to the components of the preparation.
Inflammation or bleeding in the rectum (contraindication related to the route of administration).

The criteria for the duration of treatment, along with the clinical condition, include cytochemical indicators of the activity of leukocyte enzymes in peripheral blood (succinic dehydrogenase and glycerophosphate dehydrogenase).

Possible allergic reactions - urticaria, itching, bronchospasm, dyspeptic phenomena.
If side effects occur, discontinue use of the medication and consult a doctor.

Criteria for the duration of treatment, along with clinical condition, include cytochemical indicators of the activity of leukocyte enzymes in peripheral blood (succinic dehydrogenase and glycerophosphate dehydrogenase).
Release form:
Rectal suppositories (12.5 mg + 1 mg + 6 mg). Packaged in a blister pack of polyvinyl chloride film containing 5 suppositories. Two blister packs along with the instruction manual in a cardboard box.
Storage conditions:
At a temperature not exceeding 25°C.
Keep out of reach of children.
Shelf life:
2 years.
Do not use after the expiration date indicated on the packaging.
Dispensing conditions:
By prescription.

Cases of overdose have not been reported.

Drug interactions:
No negative interactions have been noted. The drug can be used in combination therapy.

Combined preparation, the action of which is determined by the effects of the vitamins and coenzymes included in its composition, as well as their synergistic action. The preparation improves tissue metabolism in various physiological and pathological conditions that require correction with cofactors and substrates.

Cocarboxylase
Cocarboxylase is a coenzyme of thiamine (vitamin B1), which is phosphorylated in the body to form mono-, di-, and triphosphate esters. It is part of the enzymes that catalyze the carboxylation and decarboxylation of alpha-keto acids and pyruvic acid. Endogenous cocarboxylase is formed in the body from exogenous thiamine through phosphorylation; however, the properties of cocarboxylase do not fully correspond to those of thiamine, and it cannot be used for the prevention and treatment of hypovitaminosis and avitaminosis B1. Cocarboxylase improves glucose absorption, tissue trophism of the nervous system, and contributes to the normalization of cardiovascular system function. It reduces the levels of lactic and pyruvic acids in the blood (an increase in the content of these acids leads to the development of acidosis and acidotic coma).

Riboflavin
Riboflavin (vitamin B2) has a metabolic effect; it interacts with ATP to form coenzymes of flavin proteins - flavin adenine mononucleotide and flavin adenine dinucleotide, which are components of enzymes such as succinate dehydrogenase, cytochrome reductase, diaphorase, amino acid oxidases, and others. By regulating redox processes, it participates in hydrogen (H+) transfer, tissue respiration, carbohydrate, protein, and fat metabolism, maintaining normal visual function of the eye, and synthesizing hemoglobin and erythropoietin. Riboflavin-activated pyridoxal kinase converts pyridoxine (vitamin B6) into the active form pyridoxal phosphate. It contributes to the conversion of tryptophan into niacin and the maintenance of erythrocyte integrity. It is part of glutathione reductase and xanthine oxidase. It is synthesized by normal intestinal microflora and is necessary for its maintenance.

Alpha-lipoic acid
Alpha-lipoic acid (thioctic acid) is an endogenous antioxidant (it binds free radicals). It is formed in the body during the oxidative decarboxylation of alpha-keto acids. As a coenzyme of mitochondrial multi-enzyme complexes, it participates in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. In terms of biochemical action, alpha-lipoic acid is similar to B vitamins. It improves the trophism of neurons. It contributes to lowering blood glucose levels and increasing glycogen content in the liver, as well as reducing insulin resistance. It participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, improves liver function, and has a detoxifying effect in cases of poisoning with heavy metal salts and other intox

Cocarboxylase
Cocarboxylase penetrates most tissues in the body, but the highest concentration is observed in the liver, kidneys, brain, and heart. It is metabolized in the liver. The metabolites are primarily excreted by the kidneys.

Riboflavin
Riboflavin is distributed unevenly (with the highest amounts in the myocardium, liver, and kidneys). The binding to plasma proteins (mainly in the form of metabolites - flavin adenine mononucleotide and flavin adenine dinucleotide) is 60%. It crosses the placenta and is present in breast milk. It is metabolized in the liver. It is excreted by the kidneys, primarily as metabolites. The half-life is 66-84 minutes.

Thioctic Acid
Thioctic acid is metabolized in the liver through oxidation of the side chain and conjugation. The volume of distribution is approximately 450 ml/kg. The total plasma clearance is 10-15 ml/min. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half-life is 20-50 minutes.

Store in a light-protected place at a temperature not exceeding 20 °C.