Ingaron 100000 IU 5 pcs. vial lyophilisate for solution preparation for intramuscular and subcutaneous administration

- Treatment of chronic viral hepatitis C, chronic viral hepatitis B, HIV/AIDS infection, and pulmonary tuberculosis in combination therapy;
- Prevention of infectious complications in patients with chronic granulomatous disease;
- Treatment of oncological diseases in combination therapy as an immunomodulator, including in combination with chemotherapy;
- Treatment of genital herpes virus infection and shingles (Herpes zoster) in monotherapy;
- Treatment of urogenital chlamydia in combination therapy;
- Treatment of chronic prostatitis in combination therapy;
- Treatment of anogenital warts (human papillomavirus) and prevention of disease recurrence.

Administer the drug intramuscularly or subcutaneously.
Dissolve the contents of the vial in 2 ml of water for injection.
The dosage of the drug is determined individually.
For the treatment of patients with chronic viral hepatitis B, chronic viral hepatitis C, as well as HIV/AIDS infection and pulmonary tuberculosis, the average daily dose for adults is 500,000 IU. Administer once daily, either every day or every other day. The treatment course lasts from 1 to 3 months; if necessary, the treatment course is repeated after 1-2 months.
For the prevention of infectious complications in patients with chronic granulomatous disease, the average daily dose for adults is usually 500,000 IU. Administer once daily, either every day or every other day. The course consists of 5-15 injections; if necessary, the course is extended or repeated after 10-14 days.
For the treatment of oncological diseases, the average daily dose for adults is 500,000 IU. Administer once daily every other day.
For the treatment of genital herpes virus infection, shingles (herpes zoster), and urogenital chlamydia, the average daily dose for adults is 500,000 IU. Administer once daily subcutaneously, every other day. The treatment course consists of 5 injections.

1 vial
interferon gamma 100,000 IU
Excipients: mannitol.

Lyophilizate of white color, in the form of a loose or porous mass, hygroscopic.

- pregnancy;
- autoimmune diseases;
- diabetes mellitus;
- individual intolerance to gamma interferon or any other component of the drug.
Use during pregnancy and breastfeeding
The drug is contraindicated during pregnancy.

Local tenderness at the subcutaneous injection site in the form of mild aching pain (similar to overtrained muscle) and hyperemia.
The use of high doses exceeding 1,000,000 IU may be accompanied by the development of flu-like syndrome: headache, weakness, elevated body temperature, joint pain. Mild symptoms do not require pharmacological correction. In cases of pronounced symptoms - relief with paracetamol.

No data on overdose is provided.

Data on drug interactions is not provided.

Recombinant human gamma interferon consists of 144 amino acid residues, lacking the first three amino acids Cys-Tyr-Cys, which are replaced by Met. The molecular weight is 16.9 kDa. It is obtained through microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography. The specific antiviral activity on cells (human fibroblasts) infected with vesicular stomatitis virus is 2x10^7 IU/mg of protein.

Gamma interferon (immune interferon) is a crucial pro-inflammatory cytokine, produced in the human body by natural killer cells, CD4 Th1 cells, and CD8 cytotoxic suppressor cells. Gamma interferon receptors are present on macrophages, neutrophils, natural killer cells, and cytotoxic T-lymphocytes. Gamma interferon activates the effector functions of these cells, particularly their microbicidal activity, cytotoxicity, cytokine production, superoxide and nitric oxide radical production, thereby causing the death of intracellular parasites. Gamma interferon inhibits the B-cell response, interleukin-4, suppresses IgE production and CD23 antigen expression. It is an inducer of apoptosis in differentiated B-cells, which give rise to autoreactive clones. It cancels the suppressive effect of interleukin-4 on interleukin-2-dependent proliferation and generation of lymphokines from activated killers.

It activates the production of acute phase proteins of inflammation, enhances the expression of genes C2 and C4 components of the complement system. Unlike other interferons, it increases the expression of MHC class I and II antigens on various cells, inducing the expression of these molecules even on cells that do not constitutively express them. This increases the efficiency of antigen presentation and the ability of T-lymphocytes to recognize them. Gamma interferon blocks the replication of viral DNA and RNA, the synthesis of viral proteins, and the assembly of mature viral particles. Gamma interferon exerts a cytotoxic effect on virus-infected cells. Gamma interferon blocks the synthesis of beta-TGF, responsible for the development of lung and liver fibrosis.

Do not freeze.