Intestifag bottle solution for oral and rectal administration 100 ml

Treatment and prevention of gastrointestinal diseases caused by dysentery bacteria, salmonella, Escherichia coli, Proteus, enterococci, staphylococci, Pseudomonas aeruginosa, or their combination:

• bacterial dysentery;

• salmonellosis;

• dyspepsia;

• dysbiosis;

• enterocolitis, colitis.
An important condition for effective phage therapy is the prior determination of the phage sensitivity of the pathogen.

The medication is intended for oral and rectal administration. For treatment, the medication is taken orally 4 times a day, 0.5 - 1 hour before meals, starting from the first day of illness for 7-10 days.

For infants in the first months of life, during the first two days of administration, the medication is diluted with boiled water in a 1:1 ratio; if there are no side effects (regurgitation, skin rashes), the bacteriophage can be used undiluted thereafter. The medication is administered orally 3 times a day, 30 minutes before feeding. In cases of uncontrollable vomiting, the medication is used as high enemas (via a gas outlet tube or catheter) daily. A combination of rectal (as high enemas) and oral administration of the medication is possible. The treatment course lasts 7 - 10 days.

Recommended dosages of the medication:
Age Dose per administration (ml)
orally rectally
0 - 6 months 5 10
6 - 12 months 10-15 20
from 1 year to 3 years 15-20 20-30
from 3 to 8 years 20-30 30-40
from 8 years and older 30-40 50-60

In the absence of colitic syndrome, it is recommended to replace one oral dose with a single rectal administration of the age-specific dose of the medication in the form of an enema after bowel evacuation.

For preventive purposes, the optimal usage scheme is daily intake of the age-specific dose. The duration of medication intake is determined by the epidemiological situation.

If there is no improvement after treatment, or if symptoms worsen, or new symptoms appear, it is necessary to consult a doctor. Use the medication only according to the indications, method of administration, and dosages specified in the instructions.

Side effects. Allergic reactions may occur. If you experience side effects listed in the instructions or they worsen, or you notice any other side effects not listed in the instructions, inform your doctor.

In 1 ml of the preparation contains:
Active ingredient.
Sterile purified filtrates of phagolysates of S. flexneri serotypes 1, 2, 3, 4 (with activity according to Appelman - not less than 10^-6), S. sonnei, S. typhimurium (with activity according to Appelman - not less than 10^-5), S. flexneri serotype 6, other serotypes of Salmonella,
E. coli, Proteus, Enterococcus, Staphylococcus, P. aeruginosa (with activity according to Appelman - not less than 10^-4) - up to 1 ml.
Excipients.
Preservative - 8-hydroxyquinoline sulfate or 8-hydroxyquinoline sulfate monohydrate calculated as 8-hydroxyquinoline sulfate - 0.0001 g/ml (calculated content).

A clear liquid of yellow color with varying intensity, a greenish tint is permissible.

Hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding. The use of the drug is advisable in the presence of infections caused by phage-sensitive strains of bacteria (as recommended by a doctor).

An important condition for effective phage therapy is the prior determination of the pathogen's sensitivity to the bacteriophage and the early use of the preparation. The preparation is not suitable for use if the integrity of the vial is compromised, if the labeling is damaged, if the expiration date has passed, or if there is turbidity. Due to the presence of a nutrient medium in the preparation, which can allow bacteria from the environment to grow and cause turbidity, the following rules must be observed when opening the vial:

• thoroughly wash hands;

• treat the cap with an alcohol-containing solution;

• remove the cap without opening the stopper;

• do not place the stopper with the inner surface on the table or other objects;

• do not leave the vial open;

• store the opened vial only in the refrigerator.

Before use, the vial with the bacteriophage must be shaken and inspected. The preparation should be clear and free of sediment. The vial can be opened and the required volume of the preparation can be extracted using a sterile syringe by puncturing the stopper. The preparation from the opened vial, provided that storage conditions, the above rules, and the absence of turbidity are maintained, can be used throughout its shelf life.

Effect on the ability to drive vehicles and operate machinery. The preparation does not affect the ability to perform potentially hazardous activities that require increased attention and quick psychomotor reactions (including driving vehicles, working with moving machinery).

No cases of overdose have been reported to date.

The use of the drug is possible in combination with other medications and does not exclude the use of other antibacterial agents.

The drug induces specific lysis of bacteria Shigella flexneri serotypes 1, 2, 3, 4, 6; Shigella sonnei; Salmonella paratyphi A; Salmonella paratyphi B; Salmonella typhimurium; Salmonella infantis; Salmonella choleraesuis; Salmonella oranienburg; Salmonella enteritidis; enteropathogenic Escherichia coli; Proteus vulgaris; Proteus mirabilis; Enterococcus; Staphylococcus; Pseudomonas aeruginosa.

Intestifag solution for oral and rectal administration is a medicinal product intended for the treatment and prevention of gastrointestinal diseases caused by dysentery bacteria, salmonella, Escherichia coli, Proteus, enterococci, staphylococci, Pseudomonas aeruginosa, or their combinations. The product contains live bacteria that help strengthen the immune system, reduce discomfort and pain in the gastrointestinal tract, and enhance overall body tone. Intestifag can be taken both orally and rectally, depending on the doctor's recommendations and the individual needs of the patient. If there is no improvement after treatment, or if symptoms worsen, or new symptoms appear, it is necessary to consult a doctor.
Use the product only according to the indications, method of administration, and dosages specified in the instructions.

Transportation conditions. At a temperature of 2 to 8 °C; transportation at a temperature of 9 to 25 °C is allowed for no more than 1 month.
Storage conditions. At a temperature of 2 to 8 °C in a protected from light place.