PyoBacteriophage polyvalent purified 4 pcs. bottle solution for oral and external use 20 ml

Treatment and prevention of various forms of purulent-inflammatory and enteral diseases caused by bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli.
- Diseases of the gastrointestinal tract (gastroenterocolitis, cholecystitis, pancreatitis, intestinal dysbiosis);
- Inflammatory diseases in newborns and young children (gastroenterocolitis, intestinal dysbiosis, omphalitis, pemphigus, pyoderma, septicemia and septicopyemia of various localizations);
- Surgical infections (suppuration of wounds, purulent skin lesions, burns, peritonitis, pleuritis, mastitis, osteomyelitis);
- Urogenital infections (cystitis, pyelonephritis, endometritis, vulvitis, bartholinitis, colpitis, salpingo-oophoritis);
- Purulent-inflammatory diseases of the ear, throat, nose, nasal sinuses, oral cavity, pharynx, larynx, lungs, and pleura (otitis, angina, pharyngitis, stomatitis, periodontitis, sinusitis, frontal sinusitis, pneumonia, pleuritis);
- Post-traumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcer, and iridocyclitis;
- Prevention of nosocomial infections caused by bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli.
An important condition for effective phage therapy is the preliminary determination of the phage sensitivity of the pathogen.

The preparation is used for oral administration, as enemas, applications, irrigations, and for introduction into the cavities of wounds, vagina, uterus, nose, nasal sinuses, as well as into drained cavities: abscesses, abdominal cavity, pleural cavity, bladder, renal pelvis.
For oral use, the preparation is taken on an empty stomach 0.5-1 hour before meals.

RECOMMENDED DOSAGES OF THE PREPARATION

AGE OF PATIENT DOSE PER SINGLE ADMINISTRATION for various methods of administration
oral (ml) enema (ml)
0-6 months 5 10
6-12 months 10 20
From 1 year to 3 years 15 20-30
From 3 to 8 years 20 30-40
From 8 years and older 20-30 40-50
Treatment of purulent-inflammatory diseases with localized lesions should be conducted both locally and with oral administration of the preparation.
If the cavity of the purulent focus is treated with chemical antiseptics before using the bacteriophage, it should be rinsed with sterile 0.9% sodium chloride solution.
For the treatment of angina, pharyngitis, laryngitis, the preparation is used for gargling the oral cavity and throat 3 times a day at 10-20 ml, treatment course 7-10 days.
For the treatment of bronchitis, pneumonia, the preparation is taken orally 3 times a day at 10-20 ml, and is also used as aerosols and inhalations (without heating and using ultrasound), treatment course 15-20 days.
For the treatment of otitis media, the preparation is used for washing and introducing into the middle ear cavity at 2-5 ml 1-3 times a day. Treatment course 7-15 days.
For the treatment of sinusitis, the preparation is used for washing the nasal cavity, nasopharynx, and nasal sinuses at a dose of 5-10 ml and for introduction into the sinuses at 2-3 ml. The procedure is repeated daily once for 7-10 days. Additionally, the preparation is introduced into the nasal cavity in the form of tampons soaked with bacteriophage, alternately in each nasal passage and left for 0.5-1 hour. The procedure is repeated 3 times a day, treatment course 7-15 days.
For the treatment of stomatitis and chronic periodontitis, the preparation is used for rinsing the oral cavity 3-4 times a day at a dose of 10-20 ml, as well as introducing into periodontal pockets tampons soaked with bacteriophage for 5-10 minutes, treatment course 7-10 days.
For conjunctivitis and keratoconjunctivitis, the preparation is applied at 2-3 drops 4-5 times a day, treatment course 5-7 days; for purulent corneal ulcer - 4-5 drops per day for 7-10 days; for purulent iridocyclitis - 6-8 drops every 3 hours in combination with oral administration in therapeutic doses for 7-10 days.
In the case of an abscess after opening and removal of purulent contents, the preparation is introduced in an amount less than the volume of the removed pus once daily, treatment course 7-10 days.
For peritonitis and pleuritis, the preparation is introduced into drained cavities - abdominal and pleural through drainage tubes once daily at 20-70 ml, treatment course 10-15 days.
For osteomyelitis, the preparation is introduced into the wound cavity through tampons, drains at a dose of 10-30 ml once daily, treatment course 15-20 days.
For the treatment of mastitis, purulent wounds, and burns, the preparation is used for irrigation, applications, dressings, and introduction into drainage at a dose of 5-50 ml depending on the lesion site at least once a day, treatment course 10-15 days.
For the treatment of purulent-inflammatory gynecological diseases (purulent wounds, endometritis, vulvitis, bartholinitis, colpitis, salpingoophoritis), the preparation is used for irrigations, applications, and introduced into the cavities of wounds, vagina, uterus at 5-20 ml once a day for 7-10 days.
For cystitis, pyelonephritis, urethritis, the preparation is taken orally in therapeutic doses 3 times a day 1 hour before meals for 10-20 days. If the bladder or renal pelvis is drained, the preparation is introduced through a cystostomy or nephrostomy 1-3 times a day at 20-50 ml into the bladder and 5-7 ml into the renal pelvis, treatment course 7-15 days.
For gastroenterocolitis, pancreatitis, cholecystitis, as well as intestinal dysbiosis, the bacteriophage is taken orally in age-specific dosages 3 times a day 1 hour before meals for 7-15 days (as clinically indicated). In cases of intractable vomiting, the preparation is used as high enemas 2-3 times a day at 20-40 ml. In cases of intestinal dysbiosis, the preparation may be used with normal flora preparations.
To prevent nosocomial surgical infections, the preparation is used for treating postoperative and freshly infected wounds at a dose of 5-50 ml depending on the lesion site once daily for 5-7 days.
If no improvement occurs after treatment, or symptoms worsen, or new symptoms appear, it is necessary to consult a doctor. Use the preparation only according to the indications, method of use, and dosages specified in the instructions.
Use of the preparation in children under 1 year (including premature infants).
For gastroenterocolitis, pneumonia, and sepsis in newborns, the preparation is administered orally 2-3 times a day at 3-5 ml 30 minutes before feeding. In cases of intractable vomiting, the preparation is used as high enemas (via a gas outlet tube or catheter) once daily at a dose of 5-10 ml. A combination of rectal (as high enemas) and oral administration of the preparation is possible. Treatment course 7-15 days (as clinically indicated). In cases of recurrent disease, repeated treatment courses may be conducted.
For the treatment of omphalitis, pyoderma, infected wounds, the bacteriophage is used in the form of applications at 5-10 ml 2-3 times a day (a gauze napkin is soaked with bacteriophage and applied to the umbilical wound or affected skin area) for 7-15 days.
To prevent nosocomial infections in newborns, the bacteriophage is administered orally at 3-5 ml 3 times a day 30 minutes before feeding throughout the entire hospital stay.

In 1 ml of the medicinal product, there is:
Active ingredient.
A mixture of sterile purified filtrates of phagolysates from bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli - up to 1 ml.
Excipients.
8-hydroxyquinoline sulfate / 8-hydroxyquinoline sulfate monohydrate calculated as 8-hydroxyquinoline sulfate - 0.0001 g (calculated content).

A transparent yellow liquid of varying intensity, a greenish tint is permissible.

Hypersensitivity to the components of the medication.

Use during pregnancy and breastfeeding. The use of this medication during pregnancy and breastfeeding is possible in the presence of infections caused by phage-sensitive strains of bacteria (as recommended by a doctor).

Special instructions.
Before use, shake the bottle containing the bacteriophage and inspect it. The solution should be clear and free of sediment.
Attention! Do not use if the solution is cloudy!
If a portion of the bottle is needed (small doses), remove the central part of the aluminum cap with tweezers or scissors, treat the exposed surface of the rubber stopper with a cotton swab moistened with an alcohol-containing solution, and draw the required dose of the medication with a sterile syringe. A new sterile syringe with a needle should be used for each dose taken from the bottle. The medication from an opened bottle, when following the above rules, storage conditions, and in the absence of cloudiness, can be used throughout its shelf life.

Effect on the ability to drive vehicles and operate machinery.
The medication does not affect the ability to drive or engage in other potentially dangerous activities that require increased attention and quick psychomotor reactions.

Allergic reactions are possible. If you experience side effects listed in the instructions, or if they worsen, or if you notice any other side effects not mentioned in the instructions, inform your doctor.

No cases of overdose have been reported.

The drug can be used in combination with other medications, including antibiotics.

The drug induces specific lysis of the bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli.

Pyobacteriophage polyvalent is a preparation used to combat pathogenic bacteria in the human body. It contains several strains of bacteriophages aimed at destroying specific types of bacteria. The product comes in vials with a solution, each containing 6 strains of bacteriophages. Pyobacteriophage polyvalent has a powerful antimicrobial effect and is effective in treating infections caused by bacteria. It may be prescribed for the treatment of infections of the urinary tract, oral cavity, intestines, and other organs and systems of the human body. Consultation with a doctor is required before use.

Transportation conditions. At a temperature of 2 to 8°C, transportation is allowed at a temperature of 9 to 25°C for no more than 1 month.