Askovit 1 g 10 effervescent tablets

Indications

Prevention and treatment of hypo- and avitaminosis of vitamin C; As an adjunctive treatment: hemorrhagic diathesis, nasal, pulmonary, uterine, and other bleeding, acute radiation sickness; overdose of anticoagulants, slowly healing wounds and bone fractures. The drug is prescribed during increased physical and mental stress, and during the recovery period after severe and prolonged illnesses.

Method of administration and doses

Take orally, after meals, dissolving the tablet in half a glass of water beforehand. For prophylactic purposes - 500 mg/day, for therapeutic purposes - 1000 mg/day.

Composition

Ascorbic acid - 1000.00 mg
Excipients: sodium bicarbonate, sorbitol, citric acid, polyethylene glycol, saccharin, aspartame, flavoring additive "lemon", dye E-104 (quinoline yellow), E-101 (riboflavin) - for lemon flavor.

Description of the dosage form

Flat-cylindrical tablets of yellow-orange color with a pinkish tint, with lighter and darker speckles, with a facet and a score line, having a faint specific odor.

Contraindications

Increased sensitivity to the components of the drug, increased blood clotting, thrombophlebitis, tendency to thrombosis, diabetes mellitus.

Special Instructions

Products rich in ascorbic acid: citrus fruits, greens, vegetables (pepper, broccoli, cabbage, tomatoes, potatoes). During the storage of products (including prolonged freezing, drying, salting, pickling), cooking (especially in copper cookware), and chopping vegetables and fruits in salads, ascorbic acid undergoes partial degradation (during thermal processing - up to 30-50%). Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure.

With prolonged use of large doses, there may be suppression of the function of the pancreatic islet apparatus, so it should be regularly monitored during treatment.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

The administration of ascorbic acid to patients with rapidly proliferating and intensely metastasizing tumors may worsen the course of the process.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin levels, activity of "liver" transaminases, and LDH).

Side effects

Allergic reactions. Irritation of the gastrointestinal mucosa, arterial hypertension, metabolic disorders, suppression of the pancreatic islet function, thrombocytosis, thrombosis,

Interaction

Increases the concentration of benzylpenicillin and tetracyclines in the blood. Reduces the anticoagulant effect of coumarin derivatives. Improves the absorption of iron preparations in the intestine. Quinolone drugs, calcium chloride, salicylates, and corticosteroids, when used for a long time, deplete vitamin C reserves. Decreases the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid, oral contraceptives, fresh juices, and alkaline drinks reduce absorption and assimilation. Increases the risk of crystalluria when treating with salicylates and short-acting sulfonamides, slows the excretion of acids by the kidneys, and reduces the concentration of oral contraceptives in the blood.

Section: Pharmacodynamics

Ascorbic acid plays an important role in regulating redox processes, carbohydrate metabolism, blood coagulation, and tissue regeneration; it participates in the synthesis of corticosteroids, collagen, and procollagen; normalizes capillary permeability, reduces the need for vitamins B1, B2, A, E, folic acid, and pantothenic acid. It has anti-aggregant and pronounced antioxidant properties. It activates proteolytic enzymes, participates in the metabolism of aromatic amino acids, pigments, and cholesterol, and promotes the accumulation of glycogen in the liver. By activating respiratory enzymes in the liver, it enhances its detoxification and protein-forming functions, increasing prothrombin synthesis. It improves bile secretion, restores the exocrine function of the pancreas and the endocrine function of the thyroid. It promotes phagocytosis and increases the body's resistance to infections.

Section: Pharmacokinetics

After oral administration, ascorbic acid is completely absorbed from the gastrointestinal tract. It is widely distributed in the tissues of the body. The concentration of ascorbic acid in the plasma is normally approximately 10-20 mcg/ml. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and in plasma. In deficiency states, the concentration in leukocytes decreases later and more slowly and is considered a better criterion for assessing deficiency than the concentration in plasma. The binding to plasma proteins is about 25%. Ascorbic acid is reversibly oxidized to dehydroascorbic acid, part of it is metabolized to form ascorbate-2-sulfate, which is inactive, and oxalic acid, which is excreted in the urine. Ascorbic acid taken in excessive amounts is rapidly excreted unchanged in the urine, usually occurring when the daily dose exceeds 200 mg.