Canesten 1% Powder for External Use 30 g

• Fungal skin infections

• Interdigital fungal erosions

• Mycoses complicated by secondary infection

• Versicolor lichen

• Erythrasma.

Application method and doses

For external use.
Apply to previously cleaned and dry areas of the skin twice a day (in the morning and in the evening).
Candida powder can also be sprayed on clothing or shoes that are in direct contact with the affected areas.
Candida powder can be used in combination with Candida cream for external use 1% or Candida solution for external use 1%.
The duration of therapy is individual and depends on the severity and localization of the disease. To achieve complete recovery, treatment with the drug should not be stopped immediately after the acute symptoms of inflammation or subjective complaints disappear. The duration of therapy should be, on average, about 3-4 weeks. For successful treatment, regular use of the drug is important.

Composition

Each gram of the preparation contains:
Active substance: clotrimazole 10.0 mg
Excipients: purified talc 925.0 mg, corn starch 50.0 mg, colloidal silicon dioxide 10.0 mg, cosmetic fragrance 5.0 mg.

Powder from white to light yellow in color with a characteristic odor.

• Hypersensitivity to clotrimazole or other components of the drug

• First trimester of pregnancy.

Pregnancy and lactation:
Clinical and experimental studies have not established that the use of the drug during pregnancy or breastfeeding has a negative impact on the health of the woman or the fetus (child). However, the question of the appropriateness of prescribing the drug in the II or III trimester should be decided individually after consultation with a doctor. When prescribing the drug during the II or III trimesters of pregnancy, the balance between the expected benefits of the drug for the mother and the possible risks to the fetus should be considered. Application of the drug directly to the lactating breast is contraindicated.

• The medication is intended for external use only;

• Avoid contact with eyes;

• Use the medication for children under 2 years old only under the supervision of a doctor;

• In case of accidental ingestion, consult a doctor. The medication does not affect the ability to drive vehicles and engage in other potentially dangerous activities that require increased attention and quick psychomotor reactions.

Effect on the ability to operate vehicles and machinery: The medication does not affect the ability to drive vehicles and operate machinery.

Section: Side Effects

English translation:
When applied locally to the skin (rarely): erythema, tingling, burning, irritation, itching, urticaria, swelling.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not mentioned in the instructions, inform your doctor.

Overdose is unlikely.

Interaction

Clotrimazole reduces the activity of amphotericin B and other polyene antibiotics.

When used simultaneously with natamycin and nystatin, the activity of clotrimazole may be reduced.

Section: Pharmacodynamics

Pharmacological action - a broad-spectrum antifungal agent for local use, antibacterial, antiprotozoal, trichomonacidal. The antimycotic effect of the active ingredient clotrimazole (an imidazole derivative) is associated with the disruption of ergosterol synthesis, which is a component of the fungal cell membrane, altering membrane permeability and causing subsequent cell lysis. At fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in hydrogen peroxide concentration to toxic levels, which also contributes to the destruction of fungal cells.

It exhibits fungicidal and fungistatic activity against dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast-like and mold fungi (Candida spp., including Candida albicans; Torulopsis glabrata, the genus Rhodotorula, Pityrosporum orbiculare). It is active against the causative agent of tinea versicolor - Pityrosporum orbiculare (Malassezia furfur). Effective against gram-positive bacteria - the causative agent of erythrasma Corynebacterium minutissimum, as well as Staphylococcus spp., Streptococcus spp., and gram-negative bacteria - Bacteroides, Gardnerella vaginalis. At high concentrations, it is active against Trichomonas vaginalis.

Pharmacokinetics

Absorption

When applied externally, clotrimazole is poorly absorbed through the skin. The bioavailability is less than 0.5%.

Distribution

It accumulates in the stratum corneum of the epidermis at concentrations higher than the minimum inhibitory concentration (MIC) for most pathogenic fungi (50-100 mcg/ml). The concentration in the basal layer of the epidermis is 1.53-3 mcg/ml. It penetrates into the keratin of the nails.

Metabolism and Excretion

In the liver, it is biotransformed into inactive metabolites and excreted through the intestines. It is excreted through the kidneys (the proportion of renal excretion is 0.05%-0.5%). The half-life of the parent substance is 3.5-5 hours.

Description

Kandid 1% powder for external use is a medicinal product. It is a broad-spectrum antifungal agent for local application, antibacterial, antiprotozoal, and trichomonacidal.
It is recommended for conditions such as:
- Fungal skin infections
- Interdigital fungal erosions
- Mycoses complicated by secondary infection
- Pityriasis versicolor
- Erythrasma.
Apply to previously cleaned and dry areas of skin twice a day (morning and evening).
Kandid powder can also be sprayed on clothing or footwear that are in direct contact with the affected areas.
Kandid powder can be used in combination with Kandid cream for external use 1% or Kandid solution for external use 1%.
The duration of therapy is individual and depends on the severity and localization of the disease. To achieve complete recovery, treatment with the medication should not be stopped immediately after the acute symptoms of inflammation or subjective complaints disappear. The duration of therapy should average about 3-4 weeks. Regular use of the medication is important for successful treatment.
It is recommended to consult a doctor before use.